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1. (WO2012030912) 7-CYCLYLQUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/030912 International Application No.: PCT/US2011/049893
Publication Date: 08.03.2012 International Filing Date: 31.08.2011
IPC:
A61K 31/517 (2006.01) ,A61P 35/02 (2006.01) ,C07D 403/12 (2006.01) ,C07D 403/14 (2006.01) ,C07D 405/14 (2006.01) ,C07D 413/14 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
517
ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
02
specific for leukemia
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
Applicants:
AMBIT BIOSCIENCES CORPORATION [US/US]; 4215 Sorrento Valley Boulevard San Diego, CA 92121, US (AllExceptUS)
HADD, Michael, J. [US/US]; US (UsOnly)
HOLLADAY, Mark, W. [US/US]; US (UsOnly)
ROWBOTTOM, Martin [GB/US]; US (UsOnly)
Inventors:
HADD, Michael, J.; US
HOLLADAY, Mark, W.; US
ROWBOTTOM, Martin; US
Agent:
RIEGER, Dale, L.; Jones Day 222 East 41st Street New York, NY 10017-6702, US
Priority Data:
61/379,33401.09.2010US
Title (EN) 7-CYCLYLQUINAZOLINE DERIVATIVES AND METHODS OF USE THEREOF
(FR) DÉRIVÉS DE 7-CYCLYLQUINAZOLINE ET LEURS MÉTHODES D'UTILISATION
Abstract:
(EN) Provided herein are 7-cyclylquinazoline compounds for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase- mediated diseases. Also provided are pharmaceutical compositions comprising the compounds and methods of using the compounds and compositions.
(FR) La présente invention concerne des composés de 7-cyclylquinazoline pour le traitement de maladies à médiation par une JAK kinase, comprenant des maladies à médiation par la JAK2 kinase, la JAK3 kinase ou la TYK2 kinase. L'invention concerne également des compositions pharmaceutiques comprenant les composés et des méthodes d'utilisation des composés et compositions.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2611448US20130225578