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1. (WO2012027713) COMPOSITIONS AND METHODS FOR INHIBITION OF SNCA
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/027713 International Application No.: PCT/US2011/049427
Publication Date: 01.03.2012 International Filing Date: 26.08.2011
IPC:
A61K 31/713 (2006.01) ,C07H 21/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
713
Double-stranded nucleic acids or oligonucleotides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02
with ribosyl as saccharide radical
Applicants:
ALNYLAM PHARMACEUTICALS, INC. [US/US]; 300 Third Street, Third Floor Cambridge, MA 02142, US (AllExceptUS)
HINKLE, Gregory [US/US]; US (UsOnly)
BUMCROT, David [US/US]; US (UsOnly)
Inventors:
HINKLE, Gregory; US
BUMCROT, David; US
Agent:
SHUSTER, Michael, J.; Fenwick & West LLP Silicon Valley Center 801 California Street Mountain View, CA 94041, US
Priority Data:
61/377,43726.08.2010US
Title (EN) COMPOSITIONS AND METHODS FOR INHIBITION OF SNCA
(FR) COMPOSITIONS ET MÉTHODES D'INHIBITION DE LA SNCA
Abstract:
(EN) The invention relates to a double-stranded ribonucleic acid (dsRNA) targeting alpha- synuclein (SNCA) gene expression and methods of using the dsRNA to inhibit expression of SNCA.
(FR) Cette invention concerne un acide ribonucléique bicaténaire (dsRNA) ciblant l'expression génétique de l'alpha-synucléine (SNCA), et des méthodes d'utilisation du dsRNA pour inhiber l'expression de la SNCA.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)