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1. WO2012027261 - SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES

Publication Number WO/2012/027261
Publication Date 01.03.2012
International Application No. PCT/US2011/048596
International Filing Date 22.08.2011
IPC
C07D 213/30 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24with substituted hydrocarbon radicals attached to ring carbon atoms
28Radicals substituted by singly-bound oxygen or sulfur atoms
30Oxygen atoms
C07D 213/71 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
62Oxygen or sulfur atoms
70Sulfur atoms
71to which a second hetero atom is attached
C07D 213/74 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
213Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02having three double bonds between ring members or between ring members and non-ring members
04having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
60with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
72Nitrogen atoms
74Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
C07D 231/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
02not condensed with other rings
10having two or three double bonds between ring members or between ring members and non-ring members
14with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18One oxygen or sulfur atom
C07D 239/42 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32One oxygen, sulfur or nitrogen atom
42One nitrogen atom
C07D 241/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02not condensed with other rings
04having no double bonds between ring members or between ring members and non-ring members
CPC
A61P 13/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
12of the kidneys
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 15/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
08for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 27/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
A61P 27/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
27Drugs for disorders of the senses
02Ophthalmic agents
06Antiglaucoma agents or miotics
Applicants
  • AMGEN INC. [US]/[US] (AllExceptUS)
  • ASHTON, Kate [GB]/[US] (UsOnly)
  • BARTBERGER, Michael David [US]/[US] (UsOnly)
  • BO, Yunxin [CN]/[US] (UsOnly)
  • BRYAN, Marian C. [US]/[US] (UsOnly)
  • CROGHAN, Michael [US]/[US] (UsOnly)
  • FOTSCH, Christopher Harold [US]/[US] (UsOnly)
  • HALE, Clarence Henderson [US]/[US] (UsOnly)
  • KUNZ, Roxanne Kay [US]/[US] (UsOnly)
  • LIU, Longbin [US]/[US] (UsOnly)
  • NISHIMURA, Nobuko [JP]/[US] (UsOnly)
  • NORMAN, Mark H. [US]/[US] (UsOnly)
  • PENNINGTON, Lewis Dale [US]/[US] (UsOnly)
  • POON, Steve Fong [US]/[US] (UsOnly)
  • STEC, Markian Myroslaw [US]/[US] (UsOnly)
  • ST. JEAN, David, Joseph, Jr. [US]/[US] (UsOnly)
  • TAMAYO, Nuria A. [US]/[US] (UsOnly)
  • TEGLEY, Christopher Michael [US]/[US] (UsOnly)
  • YANG, Kevin Chao [US]/[US] (UsOnly)
Inventors
  • ASHTON, Kate
  • BARTBERGER, Michael David
  • BO, Yunxin
  • BRYAN, Marian C.
  • CROGHAN, Michael
  • FOTSCH, Christopher Harold
  • HALE, Clarence Henderson
  • KUNZ, Roxanne Kay
  • LIU, Longbin
  • NISHIMURA, Nobuko
  • NORMAN, Mark H.
  • PENNINGTON, Lewis Dale
  • POON, Steve Fong
  • STEC, Markian Myroslaw
  • ST. JEAN, David, Joseph, Jr.
  • TAMAYO, Nuria A.
  • TEGLEY, Christopher Michael
  • YANG, Kevin Chao
Agents
  • CRISSEY, Todd M.
Priority Data
61/376,14123.08.2010US
61/492,63402.06.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES
(FR) DÉRIVÉS DE SULFONYLPIPÉRAZINE QUI INTERAGISSENT AVEC LA PROTÉINE RÉGULATRICE DE LA GLUCOKINASE POUR LE TRAITEMENT DU DIABÈTE
Abstract
(EN)
The present invention relates to compounds of Formula I, or pharmaceutically acceptable salts thereof, that interact with glucokinase regulatory protein. In addition, the present invention relates to methods of treating type 2 diabetes, and other diseases and/or conditions where glucokinase regulatory protein is involved using the compounds, or pharmaceutically acceptable salts thereof, and pharmaceutical compositions that contain the compounds, or pharmaceutically acceptable salts thereof.
(FR)
La présente invention concerne des composés de la formule I, ou leurs sels de qualité pharmaceutique, qui interagissent avec la protéine régulatrice de la glucokinase. De plus, la présente invention concerne des méthodes de traitement du diabète de type 2, et autres maladies et/ou états où la protéine régulatrice de la glucokinase est impliquée, à l'aide des composés, ou de leurs sels de qualité pharmaceutique. L'invention concerne également des compositions pharmaceutiques qui contiennent les composés ou leurs sels de qualité pharmaceutique.
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