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1. (WO2012021942) TAM RECEPTORS AND TAM RECEPTOR LIGANDS IN DETECTION AND MODULATION OF NEUROPATHOLOGICAL DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/021942 International Application No.: PCT/AU2011/001070
Publication Date: 23.02.2012 International Filing Date: 19.08.2011
IPC:
G01N 33/68 (2006.01) ,A61K 38/17 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
Applicants:
KILPATRICK, Trevor [AU/AU]; AU (UsOnly)
PERREAU, Victoria Mary [NZ/AU]; AU (UsOnly)
FIELD, Judith [AU/AU]; AU (UsOnly)
BINDER, Michele D [AU/AU]; AU (UsOnly)
HOWARD FLOREY INSTITUTE [AU/AU]; Gate 11, Royal Parade The University of Melbourne Parkville, Victoria 3010, AU (AllExceptUS)
Inventors:
KILPATRICK, Trevor; AU
PERREAU, Victoria Mary; AU
FIELD, Judith; AU
BINDER, Michele D; AU
Agent:
HUGHES, E., John, L.; Davies Collison Cave 1 Nicholson Street Victoria, Melbourne 3000, AU
Priority Data:
201090372819.08.2010AU
Title (EN) TAM RECEPTORS AND TAM RECEPTOR LIGANDS IN DETECTION AND MODULATION OF NEUROPATHOLOGICAL DISEASE
(FR) RÉCEPTEURS TAM ET LIGANDS DE RÉCEPTEUR TAM POUR DÉTECTER ET MODULER UNE MALADIE NEUROPATHOLOGIQUE
Abstract:
(EN) Methods, compositions and kits based on TAM receptors, or TAM receptor ligands or agonists are provided for detection of neuropathological diseases or determination of their progression. The neural diseases in particular include multiple schlerosis or other inflammatory neural disorders that are characterized by demyelination, oligodendrocyte cytotoxicity and microglial activation. These methods include screening cells of a subject where identification of an elevation of expression of a TAM receptor or a change in expression of a TAM receptor ligand is diagnostic of the disease presence or progression. In addition treatment of subjects with such neuropathological diseases by administering TAM receptor ligands (such as GAS 6 or Protein S) or by administering agonists such as antibodies specific for the TAM receptors; Axl, Mer or Tyro3 is described.
(FR) L'invention concerne des méthodes, des compositions et des kits à base de récepteurs TAM ou de ligands de récepteurs TAM ou d'agonistes permettant de détecter des maladies neuropathologiques ou de déterminer leur progression. Les maladies neurales comprennent en particulier la sclérose en plaques ou d'autres troubles neuraux inflammatoires qui sont caractérisés par une démyélination, la cytotoxicité des oligodendrocytes et une activation microgliale. Ces méthodes consistent à cribler les cellules d'un sujet chez lequel l'identification d'une élévation de l'expression d'un récepteur TAM ou d'un changement d'expression d'un récepteur TAM constitue le diagnostic de la présence ou de la progression de la maladie. L'invention concerne également le traitement de sujets souffrant de maladies neuropathologiques par administration de ligands de récepteurs TAM (tels que GAS 6 ou une protéine S) ou par administration d'agonistes, tels que des anticorps spécifiques des récepteurs TAM. L'invention concerne en outre Axl, Mer ou Tyro3.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)