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1. (WO2012019188) METHODS AND COMPOSITIONS FOR THE INHIBITION OF FRUCTOKINASE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2012/019188 International Application No.: PCT/US2011/046938
Publication Date: 09.02.2012 International Filing Date: 08.08.2011
IPC:
A61K 39/395 (2006.01) ,A61K 48/00 (2006.01) ,A61K 31/7105 (2006.01) ,A61K 31/70 (2006.01) ,A61P 3/10 (2006.01) ,A61P 3/04 (2006.01) ,A61P 3/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
7105
Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
Applicants:
JOHNSON, Richard, J. [US/US]; US (UsOnly)
LANASPA, Miguel, A.; US (UsOnly)
ISHIMOTO, Takuji; US (UsOnly)
THE REGENTS OF THE UNIVERSITY OF COLORADO, a body corporate [US/US]; 1800 Grant Street, 8th Floor Denver, CO 80203, US (AllExceptUS)
Inventors:
JOHNSON, Richard, J.; US
LANASPA, Miguel, A.; US
ISHIMOTO, Takuji; US
Agent:
VAN DYKE, Timothy, H.; Beusse Wolter Sanks Mora & Maire 390 N. Orange Avenue, Ste 2500 Orlando, FL 32801, US
Priority Data:
61/371,25506.08.2010US
Title (EN) METHODS AND COMPOSITIONS FOR THE INHIBITION OF FRUCTOKINASE
(FR) PROCÉDÉS ET COMPOSITIONS DESTINÉS À L'INHIBITION DE LA FRUCTOKINASE
Abstract:
(EN) The invention relates to the use of isoform-specific fructokinase (ketohexokinase) (KHK) inhibitors alone or in combination with various agents to both prevent and treat a wide variety of diseases including, but not limited to, sugar craving, obesity, features of metabolic syndrome (including insulin resistance, hypertriglyceridemia, hypertension, and fatty liver), polyuria, proximal tubular injury, and diabetic kidney disease.
(FR) La présente invention concerne l'utilisation d'inhibiteurs de la fructokinase spécifiques d'un isoforme (cétohexokinase) (KHK) seuls ou en association avec divers agents à la fois pour prévenir et pour traiter une grande variété de maladies comprenant, mais sans s'y limiter, un besoin de sucres, l'obésité, des caractéristiques du syndrome métabolique (comprenant l'insulinorésistance, l'hypertriglycéridémie, l'hypertension, et une stéatose hépatique), la polyurie, des lésions tubulaires proximales, et une maladie rénale diabétique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)