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1. (WO2012019168) ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/019168 International Application No.: PCT/US2011/046861
Publication Date: 09.02.2012 International Filing Date: 05.08.2011
IPC:
A61K 48/00 (2006.01) ,C07H 21/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
Applicants:
MODERNA THERAPEUTICS, INC. [US/US]; One Memorial Drive 7th Floor Cambridge, MA 02142, US (AllExceptUS)
SCHRUM, Jason [US/US]; US
BANCEL, Stephane [FR/US]; US
AFEYAN, Noubar, B. [US/US]; US
Inventors:
SCHRUM, Jason; US
BANCEL, Stephane; US
AFEYAN, Noubar, B.; US
Agent:
MCCARTY, Catherine, M.; Lando & Anastasi LLP Riverfront Office Park One Main Street, Suite 1100 Cambridge, MA 02142, US
Priority Data:
61/401,05206.08.2010US
Title (EN) ENGINEERED NUCLEIC ACIDS AND METHODS OF USE THEREOF
(FR) ACIDES NUCLÉIQUES MODIFIÉS ET LEURS PROCÉDÉS D'UTILISATION
Abstract:
(EN) Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
(FR) La présente invention concerne des compositions et des procédés destinés à administrer des groupements biologiques tels que des acides nucléiques modifiés à l'intérieur de cellules afin de moduler l'expression de protéines. De telles compositions et de tels procédés comprennent l'utilisation d'ARN messagers modifiés, et sont utiles pour traiter ou prévenir des maladies, des troubles ou des états pathologiques, ou pour améliorer la santé ou le bien-être d'un sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2600901CA2807552