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1. WO2012015914 - ARYL HYDROCARBON RECEPTOR (AHR) MODIFIERS AS NOVEL CANCER THERAPEUTICS

Publication Number WO/2012/015914
Publication Date 02.02.2012
International Application No. PCT/US2011/045526
International Filing Date 27.07.2011
IPC
A61K 31/37 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
366having six-membered rings, e.g. delta-lactones
37Coumarins, e.g. psoralen
A61K 31/35 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
A61K 31/34 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
34having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
C07D 311/30 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
311Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
02ortho- or peri-condensed with carbocyclic rings or ring systems
04Benzo pyrans, not hydrogenated in the carbocyclic ring
22with oxygen or sulfur atoms directly attached in position 4
26with aromatic rings attached in position 2 or 3
28with aromatic rings attached in position 2 only
30not hydrogenated in the hetero ring, e.g. flavones
A61P 35/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 31/35
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
A61K 31/352
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
A61K 31/353
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
35having six-membered rings with one oxygen as the only ring hetero atom
352condensed with carbocyclic rings, e.g. cannabinols, methantheline
3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 35/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
02specific for leukemia
Applicants
  • TRUSTEES OF BOSTON UNIVERSITY [US]/[US] (AllExceptUS)
  • NORTHEASTERN UNIVERSITY [US]/[US] (AllExceptUS)
  • BOSTON MEDICAL CENTER CORPORATION [US]/[US] (AllExceptUS)
  • SHERR, David H. [US]/[US] (UsOnly)
  • POLLASTRI, Michael [US]/[US] (UsOnly)
  • SCHLEZINGER, Jennifer [US]/[US] (UsOnly)
  • HAIGH MOLINA, Sarah [GB]/[US] (UsOnly)
  • SCHAUS, Scott [US]/[US] (UsOnly)
  • GIGUERE, Joshua Robert [US]/[US] (UsOnly)
Inventors
  • SHERR, David H.
  • POLLASTRI, Michael
  • SCHLEZINGER, Jennifer
  • HAIGH MOLINA, Sarah
  • SCHAUS, Scott
  • GIGUERE, Joshua Robert
Agents
  • EISENSTEIN, Ronald
Priority Data
61/368,04227.07.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ARYL HYDROCARBON RECEPTOR (AHR) MODIFIERS AS NOVEL CANCER THERAPEUTICS
(FR) MODIFICATEURS DU RÉCEPTEUR D'HYDROCARBURE ARYLE (AHR) EN TANT QUE NOUVEAUX PRODUITS THÉRAPEUTIQUES ANTICANCÉREUX
Abstract
(EN)
Provided herein are novel agents that modulate AhR activity for use in therapeutic compositions and methods thereof for inhibiting cancer cell proliferation and tumor cell invasion and metastasis. The agents comprise AhR inhibitors or non-constitutive AhR agonists of Formula (I) and (II) for the inhibition of cancer cell growth and parameters that characterize tumor metastasis, such as tumor cell invasiveness.
(FR)
La présente invention concerne de nouveaux agents, qui modulent l'activité de l'AhR et qui sont destinés à être utilisés dans des compositions thérapeutiques, et des procédés associés pour inhiber la prolifération de cellules cancéreuses, ainsi que l'invasion et les métastases des cellules tumorales. Les agents comportent les inhibiteurs de l'AhR ou les agonistes de l'AhR non constitutifs des formules (I) et (II) pour l'inhibition de la croissance de cellules cancéreuses et de paramètres qui caractérisent les métastases tumorales, tels que le pouvoir envahissant des cellules tumorales.
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