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1. WO2012012642 - TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME

Publication Number WO/2012/012642
Publication Date 26.01.2012
International Application No. PCT/US2011/044864
International Filing Date 21.07.2011
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
491
Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/-C07D459/290
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
513
Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
353
3,4-Dihydrobenzopyrans, e.g. chroman, catechin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425
Thiazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
47
Quinolines; Isoquinolines
4738
ortho- or peri-condensed with heterocyclic ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
04
Anorexiants; Antiobesity agents
C07D 491/00 (2006.01)
C07D 493/00 (2006.01)
C07D 513/00 (2006.01)
A61K 31/353 (2006.01)
A61K 31/425 (2006.01)
A61K 31/4738 (2006.01)
CPC
A61K 31/335
A61K 31/35
A61K 31/397
A61K 31/4025
A61K 31/429
A61K 31/4741
Applicants
  • ZAFGEN, INC. [US/US]; One Broadway, 8th Floor Cambridge, Massachusetts 02142, US (AllExceptUS)
  • CLARK, David [GB/US]; GB (UsOnly)
  • CRAMP, Susan, Mary [GB/GB]; GB (UsOnly)
  • DYKE, Hazel, Joan [GB/GB]; GB (UsOnly)
  • PALLIN, Thomas, David [GB/GB]; GB (UsOnly)
  • ZAHLER, Robert [US/US]; US (UsOnly)
Inventors
  • CLARK, David; GB
  • CRAMP, Susan, Mary; GB
  • DYKE, Hazel, Joan; GB
  • PALLIN, Thomas, David; GB
  • ZAHLER, Robert; US
Agents
  • KAVANAUGH, Theresa, C.; Goodwin Procter LLP Exchange Place Boston, MA 02109, US
Priority Data
61/366,65022.07.2010US
61/470,09331.03.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TRICYCLIC COMPOUNDS AND METHDS OF MAKING AND USING SAME
(FR) COMPOSÉS TRICYCLIQUES ET PROCÉDÉS POUR LES PRÉPARER ET LES UTILISER
Abstract
(EN)
The invention provides tricyclic compounds and their use in treating medical disorders, such as obesity. Pharmaceutical compositions and methods of making various tricyclic compounds are provided. The compounds are contemplated to have activity against methionyl aminopeptidase 2.
(FR)
L'invention concerne des composés tricycliques et leur utilisation dans le traitement de troubles médicaux, comme l'obésité. Elle concerne des compositions pharmaceutiques et des procédés de préparation de divers composés tricycliques. Les composés sont considérés comme ayant une activité contre la méthionyle aminopeptidase 2.
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