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Pub. No.:    WO/2012/011548    International Application No.:    PCT/JP2011/066650
Publication Date: 26.01.2012 International Filing Date: 22.07.2011
C07D 215/54 (2006.01), A61K 31/4709 (2006.01), A61K 31/502 (2006.01), A61K 31/5377 (2006.01), A61P 1/16 (2006.01), A61P 21/00 (2006.01), A61P 25/28 (2006.01), A61P 43/00 (2006.01), C07D 401/12 (2006.01), C07D 471/04 (2006.01)
Applicants: The University of Tokyo [JP/JP]; 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654 (JP) (For All Designated States Except US).
Kyowa Hakko Kirin Co., Ltd. [JP/JP]; 1-6-1, Ohtemachi, Chiyoda-ku, Tokyo 1008185 (JP) (For All Designated States Except US).
ICHIJO, Hidenori [JP/JP]; (JP) (For US Only).
MAEDA, Shin [JP/JP]; (JP) (For US Only).
NAKAGAWA, Hayato [JP/JP]; (JP) (For US Only).
NAKOJI, Masayoshi [JP/JP]; (JP) (For US Only).
TAKAHASHI, Motoo [JP/JP]; (JP) (For US Only).
SHIMIZU, Toshiyuki [JP/JP]; (JP) (For US Only).
OSAWA, Tatsushi [JP/JP]; (JP) (For US Only)
Inventors: ICHIJO, Hidenori; (JP).
MAEDA, Shin; (JP).
NAKAGAWA, Hayato; (JP).
NAKOJI, Masayoshi; (JP).
SHIMIZU, Toshiyuki; (JP).
OSAWA, Tatsushi; (JP)
Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410044 (JP)
Priority Data:
2010-165514 23.07.2010 JP
(JA) 含窒素複素環誘導体
Abstract: front page image
(EN)The present invention provides a nitrogen-containing heterocyclic derivative which has ASK1-inhibitory activity and is useful as a prophylactic and/or therapeutic agent for ALS and so on, or a pharmaceutically acceptable salt thereof. The present invention provides a compound selected from among compound (1), compound (2), compound (3), compound (4), compound (6), compound (7) and compound (8), or a pharmaceutically acceptable salt thereof.
(FR)La présente invention concerne un dérivé hétérocyclique azoté présentant une activité inhibitrice de ASK1 et pouvant être employé en tant qu'agent prophylactique et/ou thérapeutique contre la SLA, etc., ou l'un de ses sels de qualité pharmaceutique. La présente invention concerne un composé choisi parmi le composé (1), le composé (2), le composé (3), le composé (4), le composé (6), le composé (7) et le composé (8), ou l'un de leurs sels de qualité pharmaceutique.
(JA) 本発明は、ASK1阻害活性を有し、例えば、ALSの予防及び/又は治療剤として有用な含窒素複素環誘導体又はその薬学的に許容される塩を提供する。本発明は、以下の化合物1、化合物2、化合物3、化合物4、化合物6、化合物7及び化合物8から選ばれる化合物又はその薬学的に許容される塩を提供する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)