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1. WO2012007954 - PROCESS FOR CINACALCET HYDROCHLORIDE

Publication Number WO/2012/007954
Publication Date 19.01.2012
International Application No. PCT/IN2010/000477
International Filing Date 16.07.2010
IPC
C07C 211/00 2006.1
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
211Compounds containing amino groups bound to a carbon skeleton
CPC
C07C 209/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
209Preparation of compounds containing amino groups bound to a carbon skeleton
24by reductive alkylation of ammonia, amines or compounds having groups reducible to amino groups, with carbonyl compounds
28by reduction with other reducing agents
C07C 209/70
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
209Preparation of compounds containing amino groups bound to a carbon skeleton
68from amines, by reactions not involving amino groups, e.g. reduction of unsaturated amines, aromatisation, or substitution of the carbon skeleton
70by reduction of unsaturated amines
C07C 209/84
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
209Preparation of compounds containing amino groups bound to a carbon skeleton
82Purification; Separation; Stabilisation; Use of additives
84Purification
C07C 45/41
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
41by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
Applicants
  • HETERO RESEARCH FOUNDATION [IN]/[IN] (AllExceptUS)
  • PARTHASARADHI REDDY , Bandi [IN]/[IN] (UsOnly)
  • RATHNAKAR REDDY, Kura [IN]/[IN] (UsOnly)
  • MURALIDHARA REDDY, Dasari [IN]/[IN] (UsOnly)
  • RAJI REDDY, Rapolu [IN]/[IN] (UsOnly)
  • MUKUNDA REDDY, Jambula [IN]/[IN] (UsOnly)
  • VAMSI KRISHNA, Bandi [IN]/[IN] (UsOnly)
Inventors
  • PARTHASARADHI REDDY , Bandi
  • RATHNAKAR REDDY, Kura
  • MURALIDHARA REDDY, Dasari
  • RAJI REDDY, Rapolu
  • MUKUNDA REDDY, Jambula
  • VAMSI KRISHNA, Bandi
Priority Data
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR CINACALCET HYDROCHLORIDE
(FR) PROCÉDÉ DE PRÉPARATION DE CHLORHYDRATE DE CINACALCET
Abstract
(EN) 3-[3-(Trifluoromethyl)phenyl]propionaldehyde is a key intermediate for the preparation of cinacalcet hydrochloride. The present invention provides a novel process for the preparation of 3-[3-(trifluoromethyl)phenyl]propionaldehyde. The present invention also provides an improved process for preparation of cinacalcet hydrochloride in high yields. The present invention further provides a process for purification of cinacalcet hydrochloride.
(FR) Le 3-[3-(trifluorométhyl)phényl]propionaldéhyde est un intermédiaire clé pour la préparation de chlorhydrate de cinacalcet. La présente invention a pour objet un nouveau procédé de préparation du 3-[3-(trifluorométhyl)phényl]propionaldéhyde. La présente invention a également pour objet un procédé amélioré de préparation du chlorhydrate de cinacalcet dans des rendements élevés. La présente invention a en outre pour objet un procédé de purification du chlorhydrate de cinacalcet.
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