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1. (WO2012004743) BENZENESULFONAMIDES USEFUL AS SODIUM CHANNEL INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2012/004743 International Application No.: PCT/IB2011/052974
Publication Date: 12.01.2012 International Filing Date: 05.07.2011
IPC:
C07D 237/20 (2006.01) ,C07D 401/12 (2006.01) ,C07D 403/12 (2006.01) ,C07D 417/12 (2006.01) ,C07D 417/14 (2006.01) ,A61K 31/501 (2006.01) ,A61P 29/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
237
Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
02
not condensed with other rings
06
having three double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
20
Nitrogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
501
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
Applicants:
PFIZER LIMITED [GB/GB]; Ramsgate Road Sandwich Kent CT13 9NJ, GB (AllExceptUS)
ICAGEN, INC [US/US]; 4222 Emperor Boulevard Suite 350 Durham, North Carolina 27703, US (AllExceptUS)
BROWN, Alan Daniel [GB/GB]; GB (UsOnly)
DE GROOT, Marcel John [NL/GB]; GB (UsOnly)
MARRON, Brian Edward [US/US]; US (UsOnly)
RAWSON, David James [GB/GB]; GB (UsOnly)
RYCKMANS, Thomas [BE/GB]; GB (UsOnly)
STORER, Robert Ian [GB/GB]; GB (UsOnly)
STUPPLE, Paul Anthony [GB/GB]; GB (UsOnly)
SWAIN, Nigel Alan [GB/GB]; GB (UsOnly)
WEST, Christopher William [US/US]; US (UsOnly)
Inventors:
BROWN, Alan Daniel; GB
DE GROOT, Marcel John; GB
MARRON, Brian Edward; US
RAWSON, David James; GB
RYCKMANS, Thomas; GB
STORER, Robert Ian; GB
STUPPLE, Paul Anthony; GB
SWAIN, Nigel Alan; GB
WEST, Christopher William; US
Agent:
DROUIN, Stephane; Pfizer Inc Five Giralda Farms Madison, NJ 07940, US
Priority Data:
61/362,92709.07.2010US
61/492,52502.06.2011US
Title (EN) BENZENESULFONAMIDES USEFUL AS SODIUM CHANNEL INHIBITORS
(FR) BENZÈNESULFONAMIDES UTILES EN TANT QU'INHIBITEURS DES CANAUX SODIQUES
Abstract:
(EN) The invention relates to sulfonamide derivatives, to their use i n medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes. More particularly the invention relates to new sulfonamide Nav1.7 inhibitors of formula (I): or pharmaceutically acceptable salts thereof, wherein Z1, Ra, Rb, R1, R2, R3, R4 and R5 are as defined in the description. Nav 1.7 inhibitors are potentially useful in the treatment of a wide range of disorders, particularly pain.
(FR) L'invention porte sur des dérivés de sulfonamide, sur leur utilisation en médecine, sur des compositions les contenant, sur des procédés pour leur préparation, et sur des intermédiaires utilisés dans ces procédés. Plus précisément, l'invention porte sur de nouveaux inhibiteurs du Nav1.7, du type sulfonamide, de formule (I), ou sur des sels pharmaceutiquement acceptables de ceux-ci, où Z1, Ra, Rb, R1, R2, R3, R4 et R5 sont tels que définis dans la description. Les inhibiteurs de Nav1.7 sont potentiellement utiles dans le traitement d'une large gamme de troubles, en particulier la douleur.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP2590951CA2804593JP2013531031