Processing

Please wait...

Settings

Settings

1. WO2012004678 - SERINE PROTEASE INHIBITORS

Publication Number WO/2012/004678
Publication Date 12.01.2012
International Application No. PCT/IB2011/002279
International Filing Date 05.07.2011
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
213
Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
02
having three double bonds between ring members or between ring members and non-ring members
04
having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
24
with substituted hydrocarbon radicals attached to ring carbon atoms
54
Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
56
Amides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55
Protease inhibitors
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50
Cyclic peptides containing at least one abnormal peptide link
54
with at least one abnormal peptide link in the ring
56
the cyclisation not occurring through 2,4-diamino-butanoic acid
C07D 213/56 (2006.01)
A61K 38/55 (2006.01)
C07K 7/56 (2006.01)
CPC
C07D 213/56
C07D 255/04
C07D 273/01
C07D 487/08
C07D 487/18
C07K 5/06
Applicants
  • THE MEDICINES COMPANY (LEIPZIG) GMBH [DE/DE]; Deutscher Platz 5d 04103 Leipzig, DE (AllExceptUS)
  • STEINMETZER, Torsten [DE/DE]; DE (UsOnly)
  • SAUPE, Sebastian, Martin [DE/DE]; DE (UsOnly)
Inventors
  • STEINMETZER, Torsten; DE
  • SAUPE, Sebastian, Martin; DE
Agents
  • BÖSL, Raphael; Isenbruck Bösl Hörschler LLP Prinzregentenstrasse 68 81675 München, DE
Priority Data
61/362,12707.07.2010US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SERINE PROTEASE INHIBITORS
(FR) INHIBITEURS DE LA SÉRINE PROTÉASE
Abstract
(EN)
The invention provides methods of making and using compounds of the formula shown, which are inhibitors of human plasmin and plasma kallikrein. (Formula I) The compounds are useful for the prevention of blood loss, and as components of fibrin adhesives.
(FR)
La présente invention concerne des procédés de fabrication et d'utilisation de composés de la formule présentée, lesdits composés étant des inhibiteurs de la kallikréine plasmatique et de la plasmine humaines. (Formule I) Les composés sont utiles pour la prévention des saignements, et en tant que composants d'adhésifs de fibrine.
Also published as
Latest bibliographic data on file with the International Bureau