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1. WO2012001438 - USE OF KYNURENIC ACID AMIDE DERIVATIVES FOR THE TREATMENT OF HUNTINGTON'S DISEASE

Publication Number WO/2012/001438
Publication Date 05.01.2012
International Application No. PCT/HU2011/000062
International Filing Date 29.06.2011
IPC
A61K 31/47 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61P 25/00 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
CPC
A61K 31/47
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
C07D 215/48
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 413/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
413Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • SZEGEDI TUDOMÁNYEGYETEM [HU]/[HU] (AllExceptUS)
  • VÉCSEI, László [HU]/[HU] (UsOnly)
  • ZÁDORI, Dénes [HU]/[HU] (UsOnly)
  • KLIVÉNYI, Péter [HU]/[HU] (UsOnly)
  • FÜLÖP, Ferenc [HU]/[HU] (UsOnly)
  • SZATMÁRI, István [HU]/[HU] (UsOnly)
  • TOLDI, József [HU]/[HU] (UsOnly)
  • FREUND, Tamás [HU]/[HU] (UsOnly)
  • NYIRI, Gábor [HU]/[HU] (UsOnly)
  • SZŐNYI, András [HU]/[HU] (UsOnly)
Inventors
  • VÉCSEI, László
  • ZÁDORI, Dénes
  • KLIVÉNYI, Péter
  • FÜLÖP, Ferenc
  • SZATMÁRI, István
  • TOLDI, József
  • FREUND, Tamás
  • NYIRI, Gábor
  • SZŐNYI, András
Agents
  • DANUBIA PATENT & LAW OFFICE LLC
Priority Data
P100034329.06.2010HU
Publication Language English (en)
Filing Language Hungarian (HU)
Designated States
Title
(EN) USE OF KYNURENIC ACID AMIDE DERIVATIVES FOR THE TREATMENT OF HUNTINGTON'S DISEASE
(FR) UTILISATION DE DÉRIVÉS D'AMIDE D'ACIDE KYNURÉNIQUE POUR LE TRAITEMENT DE LA MALADIE DE HUNTINGTON
Abstract
(EN) The invention is directed to kynurenic acid analogues and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing said compounds for treating the symptoms of Huntington's disease and preventing the development of the symptoms.
(FR) L'invention concerne des analogues d'acide kynurénique et des sels pharmaceutiquement acceptables de ceux-ci et des compositions pharmaceutiques contenant lesdits composés pour traiter les symptômes de la maladie de Huntington et prévenir le développement des symptômes.
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