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1. (WO2011163473) GLUCAGON ANALOGS EXHIBITING ENHANCED SOLUBILITY AND STABILITY IN PHYSIOLOGICAL PH BUFFERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/163473    International Application No.:    PCT/US2011/041623
Publication Date: 29.12.2011 International Filing Date: 23.06.2011
IPC:
C07K 14/605 (2006.01), A61K 38/16 (2006.01)
Applicants: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION [US/US]; 351 West 10th Street Indianapolis, IN 46202 (US) (For All Designated States Except US).
DIMARCHI, Richard, D. [US/US]; (US) (For US Only).
DIMARCHI, Maria [US/US]; (US) (For US Only).
CHABENNE, Joseph [US/US]; (US) (For US Only)
Inventors: DIMARCHI, Richard, D.; (US).
DIMARCHI, Maria; (US).
CHABENNE, Joseph; (US)
Agent: BREEN, John, P.; Barnes & Thornburg LLP 11 South Meridian Street Indianapolis, IN 46204 (US)
Priority Data:
61/358,710 25.06.2010 US
Title (EN) GLUCAGON ANALOGS EXHIBITING ENHANCED SOLUBILITY AND STABILITY IN PHYSIOLOGICAL PH BUFFERS
(FR) ANALOGUES DU GLUCAGON PRÉSENTANT UNE SOLUBILITÉ ET UNE STABILITÉ AMÉLIORÉES DANS DES TAMPONS À PH PHYSIOLOGIQUE
Abstract: front page image
(EN)Provided herein are glucagon analogs comprising a modified amino acid sequence of native human glucagon with (a) a substitution of Ser at position 16 of native glucagon (SEQ ID NO: 1) with an α,α-disubstituted amino acid, optionally alpha, aminoisobutyric acid; a substitution of the Gin at position 3 of native human glucagon (SEQ ID NO: 1) with a glutamine analog; a substitution of Arg at position 17 of native human glucagon (SEQ D NO: 1) with a negative-charged amino acid; optionally, at least one charged amino acid C-terminal to the amino acid at position 27 of the glucagon peptide; and optionally, up to 10 additional amino acid modifications. Related dimers, conjugates, fusion peptides, pharamaceutical compositions, kits, and methods of using the pharmaceutical compositions are also provided herein.
(FR)L'invention concerne des analogues du glucagon comprenant une séquence d'acides aminés du glucagon humain natif modifiée par (a) substitution de Ser en position 16 du glucagon natif (SEQ ID N° 1) par un acide aminé α,α-disubstitué, facultativement l'acide alpha-aminoisobutyrique ; substitution de Gln en position 3 du glucagon humain natif (SEQ ID N° 1) par un analogue de la glutamine ; substitution d'Arg en position 17 du glucagon humain natif (SEQ ID N° 1) par un acide aminé chargé négativement ; facultativement au moins un acide aminé chargé en position C-terminale par rapport à l'acide aminé en position 27 du peptide glucagon ; et facultativement jusqu'à 10 autres modifications d'acides aminés. L'invention concerne également des dimères apparentés, des conjugués apparentés, des peptides de fusion apparentés, des compositions pharmaceutiques apparentées, des kits apparentés, ainsi que des procédés apparentés d'utilisation des compositions pharmaceutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)