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1. (WO2011163198) TG2 INHIBITORS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/163198    International Application No.:    PCT/US2011/041208
Publication Date: 29.12.2011 International Filing Date: 21.06.2011
IPC:
A61K 31/41 (2006.01), A61K 31/381 (2006.01), A61P 35/00 (2006.01)
Applicants: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 West 7th Street Austin, TX 78701 (US) (For All Designated States Except US).
MEHTA, Kapil [US/US]; (US) (For US Only).
KUMAR, Anupam [IN/US]; (US) (For US Only).
FOK, Jansina [US/GB]; (US) (For US Only).
ZHANG, Shuxing [CN/US]; (US) (For US Only)
Inventors: MEHTA, Kapil; (US).
KUMAR, Anupam; (US).
FOK, Jansina; (US).
ZHANG, Shuxing; (US)
Agent: NIELSEN IP LAW LLC; 1177 West South Loop Suite 1600 Houston, TX 77027 (US)
Priority Data:
61/356,961 21.06.2010 US
Title (EN) TG2 INHIBITORS AND USES THEREOF
(FR) INHIBITEURS DE TG2 ET LEURS UTILISATIONS
Abstract: front page image
(EN)Methods and compounds for treating cancer, dmg resistance and/or metastasis are described herein. These methods and compounds can inhibit the expression of aberrant TG2 expression and/or inhibit the binding of GTP to TG2, and thereby prevent the induction of epithelial to mesenchymal transition of cancer cells, and a stem cell-like phenotype.
(FR)L'invention concerne des méthodes et des composés pour le traitement du cancer, de la résistance au dmg et/ou de métastases. Ces méthodes et composés peuvent inhiber l'expression d'une expression de TG2 aberrante et/ou inhiber la liaison de GTP à TG2 et empêcher ainsi l'induction de la transition épithélio-mésenchymateuse des cellules cancéreuses et d'un phénotype de type cellule souche.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)