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1. (WO2011162267) NOVEL THIOPHENECARBOXAMIDE DERIVATIVES AND USE THEREOF AS MEDICINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/162267    International Application No.:    PCT/JP2011/064183
Publication Date: 29.12.2011 International Filing Date: 21.06.2011
IPC:
C07D 417/12 (2006.01), A61K 31/427 (2006.01), A61K 31/433 (2006.01), A61K 31/4439 (2006.01), A61P 3/10 (2006.01), A61P 9/10 (2006.01), A61P 13/12 (2006.01), A61P 25/00 (2006.01), A61P 27/02 (2006.01), A61P 43/00 (2006.01), C07D 333/38 (2006.01), C07D 409/04 (2006.01), C07D 417/14 (2006.01)
Applicants: SANWA KAGAKU KENKYUSHO CO., LTD [JP/JP]; 35, Higashisotobori-cho, Higashi-ku, Nagoya-shi Aichi 4618631 (JP) (For All Designated States Except US).
KASUGAI Nobuyoshi [JP/JP]; (JP) (For US Only).
IZUCHI Tohru [JP/JP]; (JP) (For US Only).
IWAI Hisakazu [JP/JP]; (JP) (For US Only).
KATAOKA Daisuke [JP/JP]; (JP) (For US Only).
KATAOKA Hiroyo [JP/JP]; (JP) (For US Only).
KATO Noriyasu [JP/JP]; (JP) (For US Only).
KUNO Yuka [JP/JP]; (JP) (For US Only).
KOGAMI Masakazu [JP/JP]; (JP) (For US Only).
GOTO Izumi [JP/JP]; (JP) (For US Only).
KONDOH Yurie [JP/JP]; (JP) (For US Only).
SAKAIRI Masao [JP/JP]; (JP) (For US Only).
SUZUKI Kimie [JP/JP]; (JP) (For US Only).
TAKAHASHI Naoki [JP/JP]; (JP) (For US Only).
CHIKAMATSU Kaori [JP/JP]; (JP) (For US Only).
TSURUTA Nobuaki [JP/JP]; (JP) (For US Only).
NAGAI Kazushige [JP/JP]; (JP) (For US Only).
HARADA Satoko [JP/JP]; (JP) (For US Only).
HIRAMATSU Naoki [JP/JP]; (JP) (For US Only).
FUJIEDA Hiroki [JP/JP]; (JP) (For US Only).
MAKINO Mitsuhiro [JP/JP]; (JP) (For US Only).
MIYAZAWA Toshiyuki [JP/JP]; (JP) (For US Only).
MIYOSHI Mika [JP/JP]; (JP) (For US Only).
MURAKAMI Sei [JP/JP]; (JP) (For US Only).
YAMASHITA Tokuyuki [JP/JP]; (JP) (For US Only).
WATANABE Nobuhide [JP/JP]; (JP) (For US Only).
LANG Martin [DE/DE]; (DE) (For US Only).
SEIFERT Hans-Juergen Markus [DE/DE]; (DE) (For US Only).
WOLF Kaarina Kristina [DE/DE]; (DE) (For US Only)
Inventors: KASUGAI Nobuyoshi; (JP).
IZUCHI Tohru; (JP).
IWAI Hisakazu; (JP).
KATAOKA Daisuke; (JP).
KATAOKA Hiroyo; (JP).
KATO Noriyasu; (JP).
KUNO Yuka; (JP).
KOGAMI Masakazu; (JP).
GOTO Izumi; (JP).
KONDOH Yurie; (JP).
SAKAIRI Masao; (JP).
SUZUKI Kimie; (JP).
TAKAHASHI Naoki; (JP).
CHIKAMATSU Kaori; (JP).
TSURUTA Nobuaki; (JP).
NAGAI Kazushige; (JP).
HARADA Satoko; (JP).
HIRAMATSU Naoki; (JP).
FUJIEDA Hiroki; (JP).
MAKINO Mitsuhiro; (JP).
MIYAZAWA Toshiyuki; (JP).
MIYOSHI Mika; (JP).
MURAKAMI Sei; (JP).
YAMASHITA Tokuyuki; (JP).
WATANABE Nobuhide; (JP).
LANG Martin; (DE).
SEIFERT Hans-Juergen Markus; (DE).
WOLF Kaarina Kristina; (DE)
Agent: SAKAMOTO Tomohiro; 2-13, Yotsuya, Shinjuku-ku Tokyo 1600004 (JP)
Priority Data:
2010-141162 22.06.2010 JP
Title (EN) NOVEL THIOPHENECARBOXAMIDE DERIVATIVES AND USE THEREOF AS MEDICINE
(FR) NOUVEAUX DÉRIVÉS DE THIOPHÈNE-CARBOXAMIDE ET LEUR UTILISATION EN TANT QUE MÉDICAMENT
(JA) 新規チオフェンカルボキサミド誘導体及びその医薬用途
Abstract: front page image
(EN)Provided are compounds that have glucokinase-activating effect. Disclosed are pharmaceutical compositions which each contain a compound represented by general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient. In general formula (I), X is a nitrogen atom or CR2, R2 being a halogen atom, C1-6 alkyl, or the like; Y is a nitrogen atom or CR3, R3 being a hydrogen atom, C1-6 alkyl, or the like, with the proviso that when X is a nitrogen atom, Y is not a nitrogen atom; Z is a nitrogen atom or CR4, R4 being a hydrogen atom, a halogen atom, or (CH2)m-R5 [wherein m is an integer of 1 to 6 and R5 is hydroxyl or the like]; and R1 is amino, mesyl, carbamoyl, CONH-(CH2)n-A-R6 [wherein n is an integer of 1 to 6, A is nil, an oxygen atom, or the like, and R6 is C1-6 alkyl, C1-6 hydroxyalkyl, or the like], or the like.
(FR)La présente invention concerne des composés qui possèdent un effet d'activation de la glucokinase. L'invention concerne également des compositions pharmaceutiques qui contiennent chacune un composé représenté par la formule (I) générale ou l'un de ses sels pharmacologiquement acceptables en tant que principe actif. Dans la formule générale (I), X représente un atome d'azote ou CR2, R2 représentant un atome d'halogène, un groupe alkyle en C1 à C6, ou analogues ; Y représente un atome d'azote ou CR3, R3 représentant un atome d'hydrogène, un groupe alkyle en C1 à C6, ou analogues, à condition que lorsque X représente un atome d'azote, Y ne représente pas un atome d'azote ; Z représente un atome d'azote ou CR4, R4 représentant un atome d'hydrogène, un atome d'halogène ou un groupe (CH2)m-R5 [où m représente un nombre entier de 1 à 6 et R5 représente un groupe hydroxyle ou analogues] ; et R1 représente un groupe amino, mésyle, carbamoyle, CONH-(CH2)n-A-R6 [où n représente un nombre entier de 1 à 6, A est nul, un atome d'oxygène ou analogues, et R6 représente un groupe alkyle en C1 à C6, hydroxyalkyle en C1 à C6, ou analogues], ou analogues.
(JA)【課題】 本発明の課題は、グルコキナーゼ活性化作用を有する化合物を提供することである。 【解決手段】 下記一般式(I):[式中、Xは窒素原子又はCR2を、R2は、ハロゲン原子、C1-C6アルキル基等を意味する;Yは窒素原子又はCR3を、R3は、水素原子、C1-C6アルキル基等を意味する。ただし、Xが窒素原子の場合、Yは窒素原子ではない;Zは窒素原子又はCR4を、R4は水素原子、ハロゲン原子、又は(CH2)m-R5を意味する。mは1~6の整数を意味し、R5はヒドロキシ基等を意味する;R1は、アミノ基、メシル基、カルバモイル基、CONH-(CH2)n-A-R6等を意味する。nは1~6の整数を意味し、Aは、存在しないか、酸素原子等を意味し、R6は、C1-C6アルキル基、C1-C6ヒドロキシアルキル基等を意味する] で表される化合物又はその薬理学的に許容される塩を有効成分とする医薬組成物。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)