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1. (WO2011161646) PROCESS FOR THE PREPARATION OF ALVIMOPAN OR ITS PHARMACEUTICALLY ACCEPTABLE SALT OR SOLVATE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/161646    International Application No.:    PCT/IB2011/052764
Publication Date: 29.12.2011 International Filing Date: 23.06.2011
IPC:
C07C 231/02 (2006.01), C07C 235/12 (2006.01), C07C 303/28 (2006.01), C07C 309/73 (2006.01)
Applicants: RANBAXY LABORATORIES LIMITED [IN/IN]; Head Office: 12th Floor, Devika Tower 06, Nehru Place New Delhi, Delhi 110019 (IN) (For All Designated States Except US).
TIWARI, Anand Prakash [IN/IN]; (IN) (For US Only).
VERMA, Shyam Sunder [IN/IN]; (IN) (For US Only).
SINGH, Shravan Kumar [IN/IN]; (IN) (For US Only).
SINGH, Kaptan [IN/IN]; (IN) (For US Only).
PRASAD, Mohan [IN/IN]; (IN) (For US Only)
Inventors: TIWARI, Anand Prakash; (IN).
VERMA, Shyam Sunder; (IN).
SINGH, Shravan Kumar; (IN).
SINGH, Kaptan; (IN).
PRASAD, Mohan; (IN)
Common
Representative:
RANBAXY LABORATORIES LIMITED; c/o Dr. B. Vijayraghavan Intellectual Property Department 600 College Road East, Suite 2100 Princeton, NJ 08540 (US)
Priority Data:
1495/DEL/2010 25.06.2010 IN
Title (EN) PROCESS FOR THE PREPARATION OF ALVIMOPAN OR ITS PHARMACEUTICALLY ACCEPTABLE SALT OR SOLVATE THEREOF
(FR) PROCÉDÉ DE PRÉPARATION D'ALVIMOPAN OU DE SON SEL OU SOLVATE PHARMACEUTIQUEMENT ACCEPTABLE
Abstract: front page image
(EN)The present invention relates to novel intermediates, ethyl N-[(2S)-2 -benzyl-3- hydroxypropanoyl]glycinate and ethyl N-[(2S)-2-benzyl-3-{[(4-bromophenyl)sulfonyl] oxy}propanoyl]glycinate, and processes for their preparation. The present invention also relates to a process for producing alvimopan or its pharmaceutically acceptable salt or solvate thereof using these novel intermediates.(A).
(FR)Cette invention concerne de nouveaux intermédiaires, le N-[(2S)-2 -benzyl-3- hydroxypropanoyl]glycinate d'éthyle et le N-[(2S)-2-benzyl-3-{[(4-bromophényl)sulfonyl] oxy}propanoyl]glycinate d'éthyle, et leurs procédés de préparation. Cette invention concerne également un procédé de production d'alvimopan ou de son sel ou solvate pharmaceutiquement acceptable au moyen de ces nouveaux intermédiaires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)