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Machine translation
1. (WO2011161430) ASSAY FOR DETECTING FRRE LIGHT CHAINS BY CAPILLARY ZONE ELECTROPHORESIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/161430    International Application No.:    PCT/GB2011/051044
Publication Date: 29.12.2011 International Filing Date: 02.06.2011
IPC:
C07K 16/06 (2006.01), C07K 16/42 (2006.01), G01N 27/447 (2006.01), G01N 33/561 (2006.01), G01N 33/68 (2006.01)
Applicants: THE BINDING SITE GROUP LIMITED [GB/GB]; 8 Calthorpe Road Edgbaston Birmingham West Midlands B15 1QT (GB) (For All Designated States Except US).
MEAD, Graham [GB/GB]; (GB) (For US Only)
Inventors: MEAD, Graham; (GB)
Agent: WITHERS & ROGERS LLP; 4 More London Riverside London SE1 2AU (GB)
Priority Data:
1010405.7 21.06.2010 GB
Title (EN) ASSAY FOR DETECTING FRRE LIGHT CHAINS BY CAPILLARY ZONE ELECTROPHORESIS
(FR) ESSAI DE DÉTECTION DE CHAÎNES LÉGÈRES LIBRES PAR ÉLECTROPHORÈSE CAPILLAIRE DE ZONE
Abstract: front page image
(EN)The invention provides a method detecting free light chains (FLCs) comprising: (i)providing a sample from a subject; (ii)mixing the sample with an anti-FLC specific antibody, or fragments thereof capable of specifically binding the FLC, to form a mixture; (iii)passing the mixture through a capillary tube by capillary zone electrophoresis (CZE); and (iv)detecting the presence of the antibody or fragment thereof after passage through at least a portion of the capillary tube. Capillary tubes for use in CZE and kits comprising capilliary tubes and at least one anti-FLC antibody are also provided.
(FR)L'invention concerne un procédé de détection de chaînes libres légères (free light chains - FLC) comprenant : (i) l'obtention d'un échantillon d'un sujet; (ii) le mélange de l'échantillon et d'un anticorps anti-FLC spécifique ou de fragments de celui-ci en mesure de lier spécifiquement le FLC en vue de former un mélange; (iii) le passage du mélange dans un tube capillaire par électrophorèse capillaire de zone (capillary zone electrophoresis - CZE); et (iv) la détection de la présence de l'anticorps ou de son fragment après le passage au travers d'au moins une portion du tube capillaire. L'invention concerne également des tubes capillaires destinés à une utilisation dans la CZE et des kits comprenant les tubes capillaires et au moins un anticorps anti-FLC.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)