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Machine translation
1. (WO2011159871) COMPOSITIONS AND METHODS FOR THE TREATMENT OF ADDICTION, PSYCHIATRIC DISORDERS, AND NEURODEGENERATIVE DISEASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/159871    International Application No.:    PCT/US2011/040647
Publication Date: 22.12.2011 International Filing Date: 16.06.2011
IPC:
A61K 31/55 (2006.01), A61K 39/395 (2006.01), A61K 9/28 (2006.01), A61K 9/08 (2006.01), A61K 9/10 (2006.01), A61K 47/48 (2006.01), A61P 25/24 (2006.01), A61P 25/00 (2006.01)
Applicants: EMBERA NEUROTHERAPEUTICS, INC [US/US]; Biospace 1 2031 Kings Highway Shreveport, LA 71103 (US) (For All Designated States Except US).
BOARD OF SUPERVISORS OF LOUISIANA STATE UNIVERSITY & AGRICULTURAL & MECHANICAL COLLEGE [US/US]; P.O. Box 16070 Baton Rouge, LA 70893 (US) (For All Designated States Except US).
GOEDERS, Nicholas, E. [US/US]; (US) (For US Only).
FOX, Barbara, S. [US/US]; (US) (For US Only).
GUERIN, Glenn [US/US]; (US) (For US Only)
Inventors: GOEDERS, Nicholas, E.; (US).
FOX, Barbara, S.; (US).
GUERIN, Glenn; (US)
Agent: CREWS, Lee; Duane Morris LLP 100 High Street Suite 2400 Boston, MA 02110-1724 (US)
Priority Data:
61/355,482 16.06.2010 US
Title (EN) COMPOSITIONS AND METHODS FOR THE TREATMENT OF ADDICTION, PSYCHIATRIC DISORDERS, AND NEURODEGENERATIVE DISEASE
(FR) COMPOSITIONS ET PROCÉDÉS POUR LE TRAITEMENT DE L'ADDICTION, DES TROUBLES PSYCHIATRIQUES, ET D'UNE MALADIE NEURODÉGÉNÉRATIVE
Abstract: front page image
(EN)The present invention features, inter alia, pharmaceutically acceptable compositions that include metyrapol as the sole pharmaceutically active agent; compositions that include metyrapol and at least one additional pharmaceutically active agent; compositions in which the agent targeting the HPA axis is, itself, new or modified (e.g., a bi-specific antibody designed to traverse the blood-brain barrier or a known compound redesigned by, for example, conjugation to a substance that traverses the blood-brain barrier); and compositions in which the agent targeting the HPA axis is newly formulated in such a way that it fails to significantly inhibit cortisol production in the adrenal gland. For example, the composition can be formulated to include a dosage that is too low to reduce plasma cortisol levels or formulated to preferentially affect the skin.
(FR)La présente invention concerne, entre autres, des compositions pharmaceutiquement acceptables qui comprennent du métyrapol en tant que seul agent pharmaceutiquement actif; des compositions qui comprennent du métyrapol et au moins un agent pharmaceutiquement actif additionnel; des compositions dans lesquelles l'agent ciblant l'axe HPA est, lui-même, nouveau ou modifié (par exemple, un anticorps bispécifique conçu pour traverser la barrière hémato-encéphalique ou un composé connu reconçu par, par exemple, conjugaison avec une substance qui traverse la barrière hémato-encéphalique); et des compositions dans lesquelles l'agent ciblant l'axe HPA est nouvellement formulé de telle manière qu'il ne parvienne pas à inhiber efficacement la production de cortisol dans les glandes surrénales. Par exemple, la composition peut être formulée de manière à comprendre une dose qui est trop faible pour réduire les taux plasmatiques de cortisol ou formulée pour affecter de façon préférentielle la peau.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)