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1. (WO2011158973) NOVEL ANTIFIBRIN ANTIBODY

Pub. No.:    WO/2011/158973    International Application No.:    PCT/JP2011/064493
Publication Date: Dec 22, 2011 International Filing Date: Jun 17, 2011
IPC: C12N 15/09
A61K 39/395
C07K 16/18
C07K 16/46
C12N 1/15
C12N 1/19
C12N 1/21
C12N 5/10
C12P 21/08
G01N 33/53
Applicants: NATIONAL CANCER CENTER
独立行政法人国立がん研究センター
RIKEN
独立行政法人理化学研究所
MATSUMURA, Yasuhiro
松村保広
YASUNAGA, Masahiro
安永正浩
MANABE, Shino
眞鍋史乃
Inventors: MATSUMURA, Yasuhiro
松村保広
YASUNAGA, Masahiro
安永正浩
MANABE, Shino
眞鍋史乃
Title: NOVEL ANTIFIBRIN ANTIBODY
Abstract:
Provided is a novel antibody that will bind with fibrin but will not bind with fibrinogen, and also provided is a use for the novel antibody. Specifically, provided is an antibody or antigen-binding fragment thereof that binds with human fibrin and comprises: (a) H strand CDR1 formed from the amino acid sequence of sequence No. 1, or an amino acid sequence in which the same amino acid sequence contains one or several conservative amino acid substitutions; (b) H strand CDR2 formed from the amino acid sequence of sequence No. 2, or an amino acid sequence in which the same amino acid sequence contains one or several conservative amino acid substitutions; (c) H strand CDR3 formed from the amino acid sequence of sequence No. 3, or an amino acid sequence in which the same amino acid sequence contains one or several conservative amino acid substitutions; (d) L strand CDR1 formed from the amino acid sequence of sequence No. 4, or an amino acid sequence in which the same amino acid sequence contains one or several conservative amino acid substitutions; (e) L strand CDR2 formed from the amino acid sequence of sequence No. 5, or an amino acid sequence in which the same amino acid sequence contains one or several conservative amino acid substitutions; and (f) L strand CDR3 formed from the amino acid sequence of sequence No. 6, or an amino acid sequence in which the same amino acid sequence contains one or several conservative amino acid substitutions.