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1. (WO2011158720) METHOD FOR PRODUCING (1R, 2S)-1-AMINO-2-VINYL CYCLOPROPANE CARBOXYLIC ACID ESTER THAT HAS IMPROVED OPTICAL PURITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/158720    International Application No.:    PCT/JP2011/063181
Publication Date: 22.12.2011 International Filing Date: 08.06.2011
IPC:
C07C 227/42 (2006.01), C07B 57/00 (2006.01), C07C 229/48 (2006.01)
Applicants: KANEKA CORPORATION [JP/JP]; 2-4, Nakanoshima 3-chome, Kita-ku, Osaka-shi, Osaka 5308288 (JP) (For All Designated States Except US).
TANAKA, Tatsuyoshi [JP/JP]; (JP) (For US Only).
NISHIYAMA, Akira [JP/JP]; (JP) (For US Only)
Inventors: TANAKA, Tatsuyoshi; (JP).
NISHIYAMA, Akira; (JP)
Agent: UEKI, Kyuichi; Fujita-Toyobo Building 9th floor, 1-16, Dojima 2-chome, Kita-ku, Osaka-shi, Osaka 5300003 (JP)
Priority Data:
2010-136377 15.06.2010 JP
Title (EN) METHOD FOR PRODUCING (1R, 2S)-1-AMINO-2-VINYL CYCLOPROPANE CARBOXYLIC ACID ESTER THAT HAS IMPROVED OPTICAL PURITY
(FR) PROCÉDÉ DE PRODUCTION D'ESTER DE L'ACIDE (1R, 2S)-1-AMINO-2-VINYL- CYCLOPROPANE CARBOXYLIQUE DE PURETÉ OPTIQUE AMÉLIORÉE
(JA) 光学純度が高められた(1R,2S)-1-アミノ-2-ビニルシクロプロパンカルボン酸エステルの製造法
Abstract: front page image
(EN)Disclosed is a method for efficiently producing a (1R, 2S)-1-amino-2-vinyl cyclopropane carboxylic acid ester, which is useful as a pharmaceutical intermediate, at low cost. Specifically, a (1R, 2S)-1-amino-2-vinyl cyclopropane carboxylic acid ester derivative that has improved optical purity is produced by forming a salt from an optically active carboxylic acid and a 1-amino-2-vinyl cyclopropane carboxylic acid ester in a racemic form or having a low optical purity and then precipitating the salt in a solid form from the solvent.
(FR)La présente invention a pour objet un procédé de production efficace d'un ester de l'acide (1R, 2S)-1-amino-2-vinyl-cyclopropane carboxylique, utile en tant qu'intermédiaire pharmaceutique, à bas coût. De manière spécifique, un dérivé d'ester de l'acide (1R, 2S)-1-amino-2-vinyl-cyclopropane carboxylique de pureté optique améliorée est produit en formant un sel à partir d'un acide carboxylique optiquement actif et d'un ester de l'acide 1-amino-2-vinyl-cyclopropane carboxylique sous une forme racémique ou de faible pureté optique et ensuite en précipitant le sel sous forme de solide à partir du solvant.
(JA) 医薬中間体として有用な(1R,2S)-1-アミノ-2-ビニルシクロプロパンカルボン酸エステルの安価且つ効率のよい製造法を提供する。 ラセミ又は光学純度の低い1-アミノ-2-ビニルシクロプロパンカルボン酸エステルと光学活性カルボン酸から塩を形成させて、溶媒から当該塩を固体として析出させることにより、光学純度が向上した(1R,2S)-1-アミノ-2-ビニルシクロプロパンカルボン酸エステル誘導体を製造する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)