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1. (WO2011157222) JOINT DETECTION METHODS FOR LYMPHOMA FUSION GENES AND DIAGNOSTIC KITS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/157222    International Application No.:    PCT/CN2011/075849
Publication Date: 22.12.2011 International Filing Date: 17.06.2011
IPC:
C12Q 1/68 (2006.01), G01N 21/64 (2006.01), G01N 33/574 (2006.01)
Applicants: MEDI GENETECH CO., LTD. [CN/CN]; Room 305, Xiangyun Bldg. 2 Science & Technology Park, No.99 Furong Third Middle Rd., Xishan Economic Development Zone Wuxi, Jiangsu 214192 (CN) (For All Designated States Except US).
SHAO, Tang [US/CN]; (CN) (For US Only).
YUAN, Fumei [CN/CN]; (CN) (For US Only).
CHEN, Qing [CN/CN]; (CN) (For US Only)
Inventors: SHAO, Tang; (CN).
YUAN, Fumei; (CN).
CHEN, Qing; (CN)
Agent: DING & ASSOCIATES PATENT TRADEMARK & LAW; NO.13, Lane 1000, Zhang Heng Road, Zhang Jiang High-Tech Zone Pudong New District Shanghai 201203 (CN)
Priority Data:
201010202663.3 17.06.2010 CN
Title (EN) JOINT DETECTION METHODS FOR LYMPHOMA FUSION GENES AND DIAGNOSTIC KITS THEREOF
(FR) MÉTHODES DE DÉTECTION COMMUNE DE GÈNES DE FUSION DE LYMPHOME ET TROUSSES DE DIAGNOSTIC ASSOCIÉES
(ZH) 淋巴瘤融合基因的联合检测方法及其诊断试剂盒
Abstract: front page image
(EN)The invention discloses joint detection methods for lymphoma fusion genes and diagnostic kits thereof. After primers and probes for the mRNAs of lymphoma fusion genes API2-MALT1 (A1446-M814), API2-MALT1 (A1446-M1123), API2-MALT1 (A1446-M1150), NPM-ALK are designed, the probes are covalently bonded to the beads to form probe-bead mixtures, which are hybridized with the RT-PCR amplification products. After streptavidin-phycoerythrin is added, fluorescent signals from different beads can be detected, and it can be determined whether or not the sample to be detected contains the lymphoma fusion genes, and the expression profiles of the fusion genes can be determined.
(FR)L'invention concerne des méthodes de détection commune de gènes de fusion de lymphome et des trousses de diagnostic associées. Après que des amorces et des sondes pour les ARNm des gènes de fusion de lymphome API2-MALT1 (A1446-M814), API2-MALT1 (A1446-M1123), API2-MALT1 (A1446-M1150). NPM-ALK sont conçues, les sondes sont liées de manière covalente aux billes afin de former des mélanges sonde-bille qui sont hybridés avec les produits d'amplification de RT-PCR. Après l'ajout de la streptavidine-phycoérythrine, des signaux de fluorescence provenant de différentes billes peuvent être détectés et il peut être déterminé si l'échantillon à détecter contient ou non les gènes de fusion de lymphome et les profils d'expression des gènes de fusion peuvent être déterminés.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)