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1. (WO2011156889) NOVEL MODULATORS OF NRF2 AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/156889    International Application No.:    PCT/CA2011/000649
Publication Date: 22.12.2011 International Filing Date: 31.05.2011
Chapter 2 Demand Filed:    02.11.2011    
IPC:
C07D 311/22 (2006.01), A61K 31/353 (2006.01), A61K 31/381 (2006.01), A61K 31/4433 (2006.01), A61K 31/473 (2006.01), A61K 31/5025 (2006.01), A61K 31/519 (2006.01), A61K 31/52 (2006.01), C07D 219/06 (2006.01), C07D 311/38 (2006.01), C07D 405/04 (2006.01), C07D 407/04 (2006.01), C07D 409/04 (2006.01), C07D 473/00 (2006.01), C07D 473/16 (2006.01), C07D 473/24 (2006.01), C07D 473/40 (2006.01), C07D 475/00 (2006.01), C07D 487/04 (2006.01)
Applicants: TRT PHARMA INC. [CA/CA]; 2015 Peel Street 5th floor Montreal, Québec H3A 1T8 (CA) (For All Designated States Except US).
BATIST, Gerald [CA/CA]; (CA) (For US Only).
WU, Jian Hui [CA/CA]; (CA) (For US Only)
Inventors: BATIST, Gerald; (CA).
WU, Jian Hui; (CA)
Agent: BENOÎT & CÔTÉ, ASSOCIÉS INC.; #800 – 1550 Metcalfe Montréal, Québec H3A 3P1 (CA)
Priority Data:
61/354,332 14.06.2010 US
Title (EN) NOVEL MODULATORS OF NRF2 AND USES THEREOF
(FR) NOUVEAUX MODULATEURS DE LA NRF2 ET LEURS UTILISATIONS
Abstract: front page image
(EN)There is provided modulators of Nrf2 protein which comprises a compound which binds at least one of the BTB domain, IVR domain and Kelch domain of Keap1 protein, activating or inhibiting Nrf2. There is also provided pharmaceutical compositions containing the modulators, as well as uses and method of use of the modulators for the treatment of conditions.
(FR)La présente invention concerne des modulateurs de la protéine Nrf2 qui comprend un composé qui se lie à au moins l'un du domaine BTB, du domaine IVR et du domaine Kelch de la protéine Keap1, activant ou inhibant la Nrf2. L'invention concerne également des compositions pharmaceutiques contenant lesdits modulateurs, ainsi que des utilisations et une méthode d'utilisation desdits modulateurs pour le traitement d'affections.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)