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1. (WO2011156774) MULTIVALENT GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/156774    International Application No.:    PCT/US2011/040074
Publication Date: 15.12.2011 International Filing Date: 10.06.2011
IPC:
A61K 39/385 (2006.01), A61K 38/14 (2006.01), C07K 1/00 (2006.01), A61K 39/00 (2006.01)
Applicants: SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH [US/US]; 1275 York Avenue New York, NY 10021 (US) (For All Designated States Except US).
DANISHEFSKY, Samuel, J. [US/US]; (US) (For US Only).
RAGUPATHI, Govind [US/US]; (US) (For US Only).
LIVINGSTON, Philip, O. [US/US]; (US) (For US Only).
ZHU, Jianglong [CN/US]; (US) (For US Only).
IYER, Karthik [IN/US]; (US) (For US Only).
YANG, Guangbin [CN/US]; (US) (For US Only)
Inventors: DANISHEFSKY, Samuel, J.; (US).
RAGUPATHI, Govind; (US).
LIVINGSTON, Philip, O.; (US).
ZHU, Jianglong; (US).
IYER, Karthik; (US).
YANG, Guangbin; (US)
Agent: REARICK, John, P.; Choate, Hall & Stewart LLP Two International Place Boston, MA 02110 (US)
Priority Data:
61/353,722 11.06.2010 US
Title (EN) MULTIVALENT GLYCOPEPTIDE CONSTRUCTS AND USES THEREOF
(FR) CONSTRUCTIONS GLYCOPEPTIDIQUES MULTIVALENTES ET LEURS UTILISATIONS
Abstract: front page image
(EN)Glycopeptide conjugates comprising GM2 and/or Gb5 carbohydrate determinants, and methods of making and using such conjugates are disclosed. The immunogenicity of select glycopeptide conjugates is demonstrated. Vaccine compositions comprising a GM2 antigen could worsen rather than improve a subject's clinical prospects, vaccine compositions comprising GM2 in the context of inventive glycopeplides and/or glycoconjugates can show significant biological benefit in model systems. The present glycopeptide conjugates therefore provides methods of treating individuals suffering from or susceptible to certain cancers by administering a vaccine composition comprising a GM2 glycan (e.g.. in the context of a glycopeptide and/or glycoconjugate).
(FR)L'invention concerne des conjugués glycopeptidiques comprenant des déterminants glucidiques GM2 et/ou Gb5, ainsi que des procédés de fabrication et d'utilisation de ces conjugués. L'immunogénicité de conjugués glycopeptidiques sélectionnés est démontrée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)