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1. (WO2011156586) MULTILAYERED SILK SCAFFOLDS FOR MENISCUS TISSUE ENGINEERING

Pub. No.:    WO/2011/156586    International Application No.:    PCT/US2011/039786
Publication Date: Dec 15, 2011 International Filing Date: Jun 9, 2011
IPC: A61L 27/44
A61L 27/22
A61L 27/56
A61L 27/38
C12N 5/071
C12N 5/074
A61L 27/54
Applicants: TRUSTEES OF TUFTS COLLEGE
KAPLAN, David, L.
MANDAL, Biman, B.
Inventors: KAPLAN, David, L.
MANDAL, Biman, B.
Title: MULTILAYERED SILK SCAFFOLDS FOR MENISCUS TISSUE ENGINEERING
Abstract:
Provided herein is a biocompatible implant for meniscus tissue engineering. Particularly, the biocompatible implant comprises a multi-layered crescent-shaped silk fibroin scaffold, in which each layer comprises distinct pore size and/or pore orientation, e.g., to mimic native meniscus complex architecture. Accordingly, the biocompatible implant can be used for repairing any meniscal defect or promoting meniscal regeneration in a subject.