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Machine translation
1. (WO2011154333) PROCESS FOR PREPARING CRYSTALLINE 3,6,9-TRIAZA-3,6,9-TRIS(CARBOXYMETHYL)-4-(4-ETHOXYBENZYL)UNDECANEDIOIC ACID AND USE FOR PRODUCTION OF PRIMOVIST®
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/154333    International Application No.:    PCT/EP2011/059243
Publication Date: 15.12.2011 International Filing Date: 06.06.2011
IPC:
C07C 227/42 (2006.01), C07C 227/18 (2006.01), C07C 229/36 (2006.01)
Applicants: BAYER INTELLECTUAL PROPERTY GMBH [DE/DE]; Alfred-Nobel-Strasse 10 40789 Monheim (DE) (For All Designated States Except US).
PLATZEK, Johannes [DE/DE]; (DE) (For US Only).
TRENTMANN, Wilhelm [DE/DE]; (DE) (For US Only)
Inventors: PLATZEK, Johannes; (DE).
TRENTMANN, Wilhelm; (DE)
Common
Representative:
BAYER INTELLECTUAL PROPERTY GMBH; Creative Campus Monheim Alfred-Nobel-Strasse 10 40789 Monheim (DE)
Priority Data:
10 2010 023 890.2 11.06.2010 DE
PI1002466-2 19.07.2010 BR
Title (DE) VERFAHREN ZUR HERSTELLUNG KRISTALLINER 3,6,9-TRIAZA-3,6,9-TRIS(CARBOXYMETHYL)-4-(4-ETHOXYBENZYL)-UNDECANDISÄURE UND DIE VERWENDUNG ZUR HERSTELLUNG VON PRIMOVIST®
(EN) PROCESS FOR PREPARING CRYSTALLINE 3,6,9-TRIAZA-3,6,9-TRIS(CARBOXYMETHYL)-4-(4-ETHOXYBENZYL)UNDECANEDIOIC ACID AND USE FOR PRODUCTION OF PRIMOVIST®
(FR) PROCÉDÉ DE PRÉPARATION D'ACIDE 3,6,9-TRIAZA-3,6,9-TRIS(CARBOXYMÉTHYL)-4-(4-ÉTHOXYBENZYL)-UNDÉCANDIOÏQUE CRISTALLIN ET SON UTILISATION POUR LA PRÉPARATION DE PRIMOVIST®
Abstract: front page image
(DE)Die Erfindung betrifft ein Verfahren zur Herstellung kristalliner 3,6,9-Triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)-undecandisäure der Formel (I) durch Verseifung von 3,6,9-Triaza-3,6,9-tris(tert.butoxycarbonylmethyl)-4-(4-ethoxybenzyl)-undecandisäure-di-tert.-butylester der Formel (II) in einer wäßrigen Alkalimetallhydroxid-Lösung und die Verwendung von 3,6,9-Triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)-undecandisäure der Formel (I) zur Herstellung des Gadolinium-Komplex der 3,6,9-Triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)-undecandisäure [(Gd-EOB-DTPA) = Primovist®].
(EN)The invention relates to a process for preparing crystalline 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)undecanedioic acid of the formula (I) by hydrolysis of di-tert-butyl 3,6,9-triaza-3,6,9-tris(tert-butoxycarbonylmethyl)-4-(4-ethoxybenzyl)undecanedioate of the formula (II) in an aqueous alkali metal hydroxide solution, and to the use of 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)undecanedioic acid of the formula (I) for preparation of the gadolinium complex of 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)undecanedioic acid [(Gd-EOB-DTPA) = Primovist®].
(FR)La présente invention concerne un procédé de préparation d'acide 3,6,9-triaza-3,6,9-tris(carboxyméthyl)-4-(4-éthoxybenzyl)-undécandioïque cristallin de formule (I) par saponification de di-tert.-butylester d'acide 3,6,9-triaza-3,6,9-tris(tert.butoxycarbonylméthyl)-4-(4-éthoxybenzyl)-undécandioïque de formule (II) dans une solution aqueuse d'hydroxyde de métal alcalin, et l'utilisation d'acide 3,6,9-triaza-3,6,9-tris(carboxyméthyl)-4-(4-éthoxybenzyl)-undécandioïque de formule (I) pour la préparation du complexe de gadolinium de l'acide 3,6,9-triaza-3,6,9-tris(carboxyméthyl)-4-(4-éthoxybenzyl)-undécandioïque [(Gd-EOB-DTPA) = Primovist®].
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)