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1. (WO2011153348) COMPOSITION AND METHOD FOR INNER EAR SENSORY HAIR CELL REGENERATION AND REPLACEMENT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/153348    International Application No.:    PCT/US2011/038926
Publication Date: 08.12.2011 International Filing Date: 02.06.2011
Chapter 2 Demand Filed:    23.04.2012    
IPC:
C12N 15/11 (2006.01), C12N 5/071 (2010.01), C07H 21/04 (2006.01), A61K 9/50 (2006.01)
Applicants: HOUGH EAR INSTITUTE [US/US]; 3400 N.w. 56th Street Oklahoma City, OK 73112-4466 (US) (For All Designated States Except US).
KOPKE, Richard, D. [US/US]; (US) (For US Only)
Inventors: KOPKE, Richard, D.; (US)
Agent: GIBSON, Matthew, S.; Mcafee & Taft, A Professional Corporation 10th Floor - Two Leadership Square 211 North Robison Oklahoma City, OK 73102 (US)
Priority Data:
61/351,623 04.06.2010 US
Title (EN) COMPOSITION AND METHOD FOR INNER EAR SENSORY HAIR CELL REGENERATION AND REPLACEMENT
(FR) COMPOSITION ET MÉTHODE UTILISABLES EN VUE DE LA RÉGÉNÉRATION ET DU REMPLACEMENT DES CELLULES CILIÉES SENSORIELLES DE L'OREILLE INTERNE
Abstract: front page image
(EN)A composition and method for replacement and regeneration of hair cells of the inner ear is provided. The composition comprises an active agent in an amount effective to decrease Hesl gene expression in a tissue of the inner ear. The active agent can be short interfering RNA (siRNA) molecules encapsulated in a biodegradable nanoparticle. The method involves administering a solution to the inner ear where the solution contains an active agent in an amount effective to decrease Hesl gene expression.
(FR)La présente invention concerne une composition et une méthode utilisables en vue du remplacement et de la régénération des cellules ciliées sensorielles de l'oreille interne. Ladite composition contient un principe actif en quantité suffisante pour faire baisser l'expression du gène Hesl dans un tissu de l'oreille interne. Ledit principe actif peut correspondre à des molécules d'un petit ARN interférent (siARN) encapsulées dans des nanoparticules biodégradables. Ladite méthode implique d'administrer dans l'oreille interne une solution contenant un principe actif en quantité suffisante pour faire baisser l'expression du gène Hesl.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)