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Machine translation
1. (WO2011153323) COMPOSITIONS AND METHODS DIRECTED TO TREATING LIVER FIBROSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/153323    International Application No.:    PCT/US2011/038889
Publication Date: 08.12.2011 International Filing Date: 02.06.2011
IPC:
C07H 21/00 (2006.01), C12N 15/113 (2010.01), A61K 31/7088 (2006.01)
Applicants: ALNYLAM PHARMACEUTICALS, INC. [--/US]; 300 Third Street Third Floor Cambridge, MA 02142 (US) (For All Designated States Except US).
HINKLE, Greg [US/US]; (US) (For US Only).
KOTELIANSKI, Victor [US/US]; (US) (For US Only).
BETTENCOURT, Brian [US/US]; (US) (For US Only).
SEHGAL, Alfica [IN/US]; (US) (For US Only).
NOVOBRANTSEVA, Tatiana [US/US]; (US) (For US Only)
Inventors: HINKLE, Greg; (US).
KOTELIANSKI, Victor; (US).
BETTENCOURT, Brian; (US).
SEHGAL, Alfica; (US).
NOVOBRANTSEVA, Tatiana; (US)
Agent: RESNICK, David; Nixon Peabody LLP 100 Summer Street Boston, MA 02110 (US)
Priority Data:
61/350,829 02.06.2010 US
61/371,481 06.08.2010 US
61/408,271 29.10.2010 US
Title (EN) COMPOSITIONS AND METHODS DIRECTED TO TREATING LIVER FIBROSIS
(FR) COMPOSITIONS ET MÉTHODES POUR TRAITER UNE FIBROSE HÉPATIQUE
Abstract: front page image
(EN)The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the COL1A1, TGF-β, and SMAD2/3 genes, and methods of using such dsRNA compositions to inhibit expression of COL1A1, TGF-β, and SMAD2/3.
(FR)L'invention concerne des compositions d'acide ribonucléique double brin (ARNdb) ayant pour cible les gènes de COL1A1, TGF-β et SMAD2/3. Cette invention se rapporte en outre à des méthodes d'utilisation de ces compositions d'ARNdb pour inhiber l'expression de COL1A1, TGF-β et SMAD2/3.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)