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Machine translation
1. (WO2011152995) SYNTHETIC PROTEINS CONTAINING T CELL EPITOPES FOR USE AS IMMUNOGENIC COMPOSITIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/152995    International Application No.:    PCT/US2011/037049
Publication Date: 08.12.2011 International Filing Date: 18.05.2011
IPC:
A61K 38/00 (2006.01)
Applicants: BOLT BIOPHARMA, INC. [US/US]; 19223 - 55th Avenue N.E. Lake Forest Park, Washington 98155 (US) (For All Designated States Except US).
ALLISON, Daniel Scott [US/US]; (US) (For US Only)
Inventors: ALLISON, Daniel Scott; (US)
Agent: SLEATH, Janet; Speckman Law Group PLLC 2014B East Union Street Seattle, Washington 98122 (US)
Priority Data:
61/351,404 04.06.2010 US
Title (EN) SYNTHETIC PROTEINS CONTAINING T CELL EPITOPES FOR USE AS IMMUNOGENIC COMPOSITIONS
(FR) PROTÉINES SYNTHÉTIQUES CONTENANT DES ÉPITOPES DE CELLULES T DESTINÉES À ÊTRE UTILISÉES EN TANT QUE COMPOSITIONS IMMUNOGÈNES
Abstract: front page image
(EN)Synthetic protein domains containing one or more T cell epitopes are provided, together with immunogenic compositions including such domains and methods for the treatment of infectious diseases and/or cancer using such immunogenic compositions. The synthetic proteins contain CD4 and/or CD8 T cell epitopes from the proteome of an infectious disease organism or from a tumor-associated antigen, together with an artificial, non-human-like polypeptide scaffold sequence which, when expressed in a recombinant expression system, generate well-folded, stable, and non-aggregated polypeptides.
(FR)La présente invention concerne des domaines protéiques de synthèse contenant un ou plusieurs épitopes de cellules T, conjointement à des compositions immunogènes comprenant ces domaines et des procédés de traitement de maladies infectieuses et/ou de cancer en utilisant ces compositions immunogènes. Les protéines de synthèse contiennent des épitopes des cellules T CD4 et/ou CD8 du protéome d'un organisme responsable de maladies infectieuses ou d'un antigène associé aux tumeurs, conjointement à une séquence d'échafaudage polypeptidique artificielle, de type non humain, qui, lorsqu'elle est exprimée dans un système d'expression recombinant, génère des polypeptides stables, bien pliés et ne s'agrégeant pas.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)