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1. (WO2011152272) METHOD OF DETERMINING THE RISK OF ADVERSE EFFECTS OF IRINOTECAN, AND KIT THEREFORE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/152272    International Application No.:    PCT/JP2011/062067
Publication Date: 08.12.2011 International Filing Date: 26.05.2011
IPC:
C12Q 1/68 (2006.01), C12N 15/09 (2006.01), G01N 33/53 (2006.01)
Applicants: TOYO KOHAN CO., LTD. [JP/JP]; 2-12, Yonban-cho, Chiyoda-ku, Tokyo 1028447 (JP) (For All Designated States Except US).
YAMAGUCHI UNIVERSITY [JP/JP]; 1677-1, Yoshida, Yamaguchi-shi, Yamaguchi 7538511 (JP) (For All Designated States Except US).
OKA Masaaki [JP/JP]; (JP) (For US Only).
HAZAMA Shoichi [JP/JP]; (JP) (For US Only).
TSUNEDOMI Ryouichi [JP/JP]; (JP) (For US Only).
HAMAMOTO Yoshihiko [JP/JP]; (JP) (For US Only).
FUJITA Yusuke [JP/JP]; (JP) (For US Only).
HIRAYAMA Koichi [JP/JP]; (JP) (For US Only).
ITO Akane [JP/JP]; (JP) (For US Only)
Inventors: OKA Masaaki; (JP).
HAZAMA Shoichi; (JP).
TSUNEDOMI Ryouichi; (JP).
HAMAMOTO Yoshihiko; (JP).
FUJITA Yusuke; (JP).
HIRAYAMA Koichi; (JP).
ITO Akane; (JP)
Agent: HIRAKI Yusuke; Atago Green Hills MORI Tower 32F, 5-1, Atago 2-chome, Minato-ku, Tokyo 1056232 (JP)
Priority Data:
2010-125720 01.06.2010 JP
Title (EN) METHOD OF DETERMINING THE RISK OF ADVERSE EFFECTS OF IRINOTECAN, AND KIT THEREFORE
(FR) MÉTHODE PERMETTANT DE DÉTERMINER LE RISQUE D'EFFETS SECONDAIRES DE L'IRINOTÉCAN, ET KIT AFFÉRENT
(JA) イリノテカンの副作用の発生危険度を判定する方法及びそのためのキット
Abstract: front page image
(EN)The disclosed method accurately determines the risk of adverse effects of irinotecan by detecting polymorphisms of UDP-glucuronosyltransferase. It is determined whether the type of the aforementioned gene polymorphism in the aforementioned subject is normal, hetero or mutant by means of a hybridization method of a pair of nucleic acid probes, which are for determining the wild-types and mutant-types of the gene polymorphisms UGT1A1*28, UGT1A1*6, UGT1A1*27 and UGT1A1*60 in UDP-glucuronosyltransferase gene, and of the amplified nucleic acids, which are obtained by means of amplification reaction having as a template the genomic DNA from a biological sample of the subject.
(FR)Cette invention concerne une méthode permettant de déterminer avec précision le risque d'effets secondaires de l'irinotécan par détection des polymorphismes de l'UDP-glucuronosyltransférase. Le type de polymorphisme du gène précité chez le sujet précité est jugé normal, hétéro ou mutant par un procédé d'hybridation d'une paire de sondes d'acides nucléiques, conçues pour déterminer les types sauvages et les types mutants des polymorphismes géniques UGT1A1*28, UGT1A1*6, UGT1A1*27 et UGT1A1*60 dans le gène de l'UDP-glucuronosyltransférase, et des acides nucléiques amplifiés, qui sont obtenus par une réaction d'amplification utilisant comme matrice l'ADN génomique provenant d'un échantillon biologique du sujet.
(JA) グルクロン酸抱合酵素遺伝子の多型を検出することによりイリノテカンによる副作用の発生危険度を判定するに際して、より高精度に判定する。 グルクロン酸抱合酵素遺伝子における以下の遺伝子多型:UGT1A1*28;UGT1A1*6;UGT1A1*27;UGT1A1*60の野生型及び変異型を判定する一対の核酸プローブと、被検者の生体試料由来のゲノムDNAを鋳型とする増幅反応によって得られた増幅核酸とのハイブリダイゼーション法により、上記被検者における上記各遺伝子多型が正常型、ヘテロ型及び変異型のいずれであるか判定する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)