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Machine translation
1. (WO2011151814) CAGED CELL PENETRATING PEPTIDE-POLYMER CONJUGATES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/151814    International Application No.:    PCT/IL2011/000413
Publication Date: 08.12.2011 International Filing Date: 26.05.2011
IPC:
A61K 38/00 (2006.01), C07K 1/00 (2006.01)
Applicants: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY [IL/IL]; P.O. Box 653 Beer Sheva 84105 (IL) (For All Designated States Except US).
DAVID, Ayelet [IL/IL]; (IL) (For US Only).
ASHKENASY, Gonen [IL/IL]; (IL) (For US Only).
SHAMAY, Yossi [IL/IL]; (IL) (For US Only)
Inventors: DAVID, Ayelet; (IL).
ASHKENASY, Gonen; (IL).
SHAMAY, Yossi; (IL)
Agent: WOLF BREGMAN AND GOLLER; P. O. Box 1352 Jerusalem 91013 (IL)
Priority Data:
61,349,819 29.05.2010 US
Title (EN) CAGED CELL PENETRATING PEPTIDE-POLYMER CONJUGATES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS
(FR) CONJUGUÉS PEPTIDE-POLYMÈRE BLOQUÉS DE PÉNÉTRATION CELLULAIRE POUR DIAGNOSTIC ET APPLICATIONS THÉRAPEUTIQUES
Abstract: front page image
(EN)The caged cell-penetrating peptide (cCPP) conjugates of this invention are ideal for intracellular delivery of a broad variety of cargoes including various nanoparticulate pharmaceutical carriers (liposomes, micelles, microparticles, nanoparticles, polymer-conjugates). The conjugates comprise a detectable agent or a therapeutic agent, and the conjugates provide a novel strategy for site-specific delivery of the same to appropriate tissues in the subject. Versatile application of the conjugates in diagnostics and imaging is described.
(FR)Les conjugués peptidiques de pénétration cellulaire bloqués (cCPP) de l'invention s'utilisent idéalement pour l'administration intracellulaire d'une grande variété de cargaisons comprenant divers excipients pharmaceutiques nanoparticulaires (liposomes, micelles, microparticules, nanoparticules, conjugués de polymère). Les conjugués comprennent un agent décelable ou un agent thérapeutique, et les conjugués offrent une nouvelle stratégie pour une administration spécifique à des tissus ciblés d'un sujet. On décrit une application polyvalente des conjugués à des fins de diagnostic et d'imagerie.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)