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1. (WO2011151360) AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/151360    International Application No.:    PCT/EP2011/059009
Publication Date: 08.12.2011 International Filing Date: 01.06.2011
IPC:
C07D 403/14 (2006.01), C07D 473/16 (2006.01), A61K 31/52 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (For All Designated States Except US).
BAKER-GLENN, Charles [GB/GB]; (GB) (For US Only).
BURDICK, Daniel Jon [US/US]; (US) (For US Only).
CHAMBERS, Mark [GB/GB]; (GB) (For US Only).
CHAN, Bryan K. [CA/US]; (US) (For US Only).
CHEN, Huifen [US/US]; (US) (For US Only).
ESTRADA, Anthony [US/US]; (US) (For US Only).
GUNZNER, Janet L. [US/US]; (US) (For US Only).
SHORE, Daniel [CA/US]; (US) (For US Only).
SWEENEY, Zachary Kevin [US/US]; (US) (For US Only).
WANG, Shumei [CA/US]; (US) (For US Only).
ZHAO, Guiling [US/US]; (US) (For US Only)
Inventors: BAKER-GLENN, Charles; (GB).
BURDICK, Daniel Jon; (US).
CHAMBERS, Mark; (GB).
CHAN, Bryan K.; (US).
CHEN, Huifen; (US).
ESTRADA, Anthony; (US).
GUNZNER, Janet L.; (US).
SHORE, Daniel; (US).
SWEENEY, Zachary Kevin; (US).
WANG, Shumei; (US).
ZHAO, Guiling; (US)
Agent: MUELLER-AFRAZ, Simona; F. Hoffmann-la Roche Ag Grenzacherstrasse 124 CH-4070 Basel (CH)
Priority Data:
61/351,530 04.06.2010 US
61/482,455 04.05.2011 US
Title (EN) AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS
(FR) DÉRIVÉS D'AMINOPYRIMIDINE AU TITRE DE MODULATEURS DE LRRK2
Abstract: front page image
(EN)Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
(FR)L'invention concerne des composés de formule I : ou leurs sels de qualité pharmaceutique, où m, n, X, R1, R2, R3, R5, R6 et R7 sont tels que définis dans la présente. La présente invention concerne également des procédés de fabrication desdits composés et d'utilisation desdits composés dans le traitement de maladies associées au récepteur LRRK2, comme la maladie de Parkinson.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)