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1. WO2011151360 - AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS

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Publication Number WO/2011/151360
Publication Date 08.12.2011
International Application No. PCT/EP2011/059009
International Filing Date 01.06.2011
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
473
Heterocyclic compounds containing purine ring systems
02
with oxygen, sulfur, or nitrogen atoms directly attached in positions 2 and 6
16
two nitrogen atoms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
52
Purines, e.g. adenine
C07D 403/14 (2006.01)
C07D 473/16 (2006.01)
A61K 31/52 (2006.01)
CPC
C07D 239/47
C07D 239/48
C07D 401/12
C07D 403/12
C07D 403/14
C07D 405/12
Applicants
  • F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
  • BAKER-GLENN, Charles [GB/GB]; GB (UsOnly)
  • BURDICK, Daniel Jon [US/US]; US (UsOnly)
  • CHAMBERS, Mark [GB/GB]; GB (UsOnly)
  • CHAN, Bryan K. [CA/US]; US (UsOnly)
  • CHEN, Huifen [US/US]; US (UsOnly)
  • ESTRADA, Anthony [US/US]; US (UsOnly)
  • GUNZNER, Janet L. [US/US]; US (UsOnly)
  • SHORE, Daniel [CA/US]; US (UsOnly)
  • SWEENEY, Zachary Kevin [US/US]; US (UsOnly)
  • WANG, Shumei [CA/US]; US (UsOnly)
  • ZHAO, Guiling [US/US]; US (UsOnly)
Inventors
  • BAKER-GLENN, Charles; GB
  • BURDICK, Daniel Jon; US
  • CHAMBERS, Mark; GB
  • CHAN, Bryan K.; US
  • CHEN, Huifen; US
  • ESTRADA, Anthony; US
  • GUNZNER, Janet L.; US
  • SHORE, Daniel; US
  • SWEENEY, Zachary Kevin; US
  • WANG, Shumei; US
  • ZHAO, Guiling; US
Agents
  • MUELLER-AFRAZ, Simona; F. Hoffmann-la Roche Ag Grenzacherstrasse 124 CH-4070 Basel, CH
Priority Data
61/351,53004.06.2010US
61/482,45504.05.2011US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS
(FR) DÉRIVÉS D'AMINOPYRIMIDINE AU TITRE DE MODULATEURS DE LRRK2
front page image
Abstract
(EN)
Compounds of the formula I: or pharmaceutically acceptable salts thereof, wherein m, n. X, R1, R2, R3, R5, R6 and R7 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with LRRK2 receptor, such as Parkinson's disease.
(FR)
L'invention concerne des composés de formule I : ou leurs sels de qualité pharmaceutique, où m, n, X, R1, R2, R3, R5, R6 et R7 sont tels que définis dans la présente. La présente invention concerne également des procédés de fabrication desdits composés et d'utilisation desdits composés dans le traitement de maladies associées au récepteur LRRK2, comme la maladie de Parkinson.
Also published as
AU2011260323
BR112012030820
CA2797947
CL2012003293
CN103038230
CO12188550
CRCR2012-000591
DK2576541
EA201291220
EP2576541
EP3075730
ES2577829
IL222686
IN10126/CHENP/2012
JP2013530954
KR1020130041063
MX2012014158
MYPI 2012005053
PE2013-0235
PH1/2012/502373
PH12012502373
RSP-2016/0475
SG185641
TH1201006278
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