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1. (WO2011151356) METHODS FOR THE PREPARATION OF INJECTABLE DEPOT COMPOSITIONS

Pub. No.:    WO/2011/151356    International Application No.:    PCT/EP2011/059001
Publication Date: Dec 8, 2011 International Filing Date: May 31, 2011
IPC: A61K 47/34
Applicants: LABORATORIOS FARMACÉUTICOS ROVI, S.A.
GUTIERRO ADURIZ, Ibon
GÓMEZ OCHOA, María, Teresa
Inventors: GUTIERRO ADURIZ, Ibon
GÓMEZ OCHOA, María, Teresa
Title: METHODS FOR THE PREPARATION OF INJECTABLE DEPOT COMPOSITIONS
Abstract:
Injectable depot compositions, comprising a biocompatible polymer which is a polymer or copolymer based on lactic acid and/or lactic acid plus glycolic acid having a monomer ratio of lactic to glycolic acid in the range from 48:52 to 100:0, a water- miscible solvent having a dipole moment of about 3.7-4.5 D and a dielectric constant of between 30 and 50, and a drug, were found suitable for forming in-situ biodegradable implants which can evoke therapeutic drug plasma levels from the first day and for at least 14 days.