WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2011151344) METHOD OF IN-VITRO EVALUATION OF THE PHYSIOLOGICAL STATE OF A GASTRIC MUCOUS MEMBRANE AND KIT FOR CARRYING OUT SUCH AN EVALUATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/151344    International Application No.:    PCT/EP2011/058984
Publication Date: 08.12.2011 International Filing Date: 31.05.2011
IPC:
G01N 33/50 (2006.01), G01N 33/68 (2006.01)
Applicants: INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE [FR/FR]; 147 rue de l'Université F-75007 Paris Cedex 07 (FR) (For All Designated States Except US).
CHU NANTES [FR/FR]; 5 Allée de l'Ile Gloriette F-44000 Nantes (FR) (For All Designated States Except US).
UNIVERSITE DE NANTES [FR/FR]; 1 Quai de Tourville F-44000 Nantes (FR) (For All Designated States Except US).
KAEFFER, Bertrand [FR/FR]; (FR) (For US Only).
ROZE, Jean-Christophe [FR/FR]; (FR) (For US Only)
Inventors: KAEFFER, Bertrand; (FR).
ROZE, Jean-Christophe; (FR)
Agent: FOURCADE, Emmanuelle; Parc de Basso Cambo 4, Rue Paul Mesplé F-31100 Toulouse (FR)
Priority Data:
1054245 01.06.2010 FR
Title (EN) METHOD OF IN-VITRO EVALUATION OF THE PHYSIOLOGICAL STATE OF A GASTRIC MUCOUS MEMBRANE AND KIT FOR CARRYING OUT SUCH AN EVALUATION
(FR) PROCÉDÉ D'ÉVALUATION IN VITRO DE L'ÉTAT PHYSIOLOGIQUE D'UNE MUQUEUSE GASTRIQUE ET KIT POUR RÉALISER UNE TELLE ÉVALUATION
Abstract: front page image
(EN)The invention relates to a method of in-vitro evaluation of the physiological state of a gastric mucous membrane on the basis of exfoliated cells isolated from a biological fluid of a human or nonhuman animal individual, according to which said cells are subjected to a set of antibodies able to interact with protein markers from among at least one autophagia marker and at least one clock marker. Advantageously, anti-SURVIVIN antibodies and/or anti-LC3 antibodies are used as autophagia markers. Likewise, anti-PERIOD1 antibodies and/or anti-CLOCK antibodies are used as clock markers. The invention also relates to a kit comprising a set of antibodies capable of being used for said method.
(FR)L'invention concerne un procédé d'évaluation in vitro de l'état physiologique d'une muqueuse gastrique à partir de cellules exfoliées et isolées d'un fluide biologique d'un individu animal, humain ou non humain, selon lequel on soumet lesdites cellules à un ensemble d'anti-corps susceptibles d'interagir avec des marqueurs protéiques parmi au moins un marqueur de l'autophagie et au moins un marqueur de l'horloge. Avantageusement, on utilise des anticorps anti-SURVIVINE et/ou des anticorps anti-LC3, en tant que marqueurs de l'autophagie. De même, on utilise des anticorps anti-PERIOD1 et/ou des anticorps anti-CLOCK, en tant que marqueurs de l'horloge. L'invention concerne également un kit comportant un ensemble d'anti-corps susceptibles d'être utilisés pour ledit procédé.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: French (FR)
Filing Language: French (FR)