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Pub. No.:    WO/2011/150183    International Application No.:    PCT/US2011/038099
Publication Date: 01.12.2011 International Filing Date: 26.05.2011
C07D 251/30 (2006.01), C07D 251/52 (2006.01), C07D 263/58 (2006.01), C07D 277/74 (2006.01), C07D 277/82 (2006.01), C07D 401/06 (2006.01), C07D 401/12 (2006.01), C07D 401/14 (2006.01), C07D 403/12 (2006.01), C07D 413/12 (2006.01), C07D 417/12 (2006.01), A61K 31/496 (2006.01), A61K 51/04 (2006.01), A61P 25/00 (2006.01)
Applicants: GE HEALTHCARE LIMITED [GB/GB]; Amersham Place Little Chalfont Buckinghamshire HP7 9NA (GB) (For All Designated States Except US).
MEDI-PHYSICS, INC. [US/US]; 101 Carnegie Center Princeton, New Jersey 08540 (US) (MG only).
NEWINGTON, Ian, Martin [GB/GB]; (GB) (For US Only).
WYNN, Duncan George [GB/GB]; (GB) (For US Only).
NAIRNE, Robert James Domett [GB/GB]; (GB) (For US Only).
GUILBERT, Benedicte [FR/GB]; (GB) (For US Only).
MANDAL, Subrata [IN/IN]; (IN) (For US Only).
JOSE, Jinto [IN/IN]; (IN) (For US Only).
VARADARAJAN, Sunderaraman [IN/IN]; (IN) (For US Only).
RANGASWAMY, Chitralekha [IN/IN]; (IN) (For US Only).
BETTS, Helen [GB/GB]; (GB) (For US Only).
DAVIS, Rebecca [GB/GB]; (GB) (For US Only)
Inventors: NEWINGTON, Ian, Martin; (GB).
WYNN, Duncan George; (GB).
NAIRNE, Robert James Domett; (GB).
GUILBERT, Benedicte; (GB).
MANDAL, Subrata; (IN).
JOSE, Jinto; (IN).
VARADARAJAN, Sunderaraman; (IN).
RANGASWAMY, Chitralekha; (IN).
BETTS, Helen; (GB).
DAVIS, Rebecca; (GB)
Agent: CHISHOLM, Robert; GE Healthcare, Inc. IP Department 101 Carnegie Center Princeton, New Jersey 08540 (US)
Priority Data:
1232/DEL/2010 28.05.2010 IN
1231/DEL/2010 28.05.2010 IN
Abstract: front page image
(EN)The present invention relates to radiodiagnostic compounds, methods of making those compounds, and methods of use thereof as imaging agents for preferably a HA serotonin 5-HT1A receptor for use in PET or SPECT, preferably PET. Compositions comprising an imaging-effective amount of radiolabeled compounds are also disclosed. The present invention also relates to non-radiolabeled compounds, methods of making those compounds, and methods of use thereof to treat various neurological and/or psychiatric disorders.
(FR)La présente invention concerne des composés de radiodiagnostic, des procédés de fabrication de ces composés et leurs procédés d'utilisation en tant qu'agents d'imagerie pour, de préférence, un récepteur 5-HT1A de la sérotonine marqué à l'hémaglutirine (HA) pour utilisation en tomographie par émission de positons (PET) ou tomographie monophotonique d'émission (SPECT), de préférence PET. L'invention concerne également des compositions comportant une quantité efficace pour l'imagerie de composés radiomarqués. La présente invention concerne également des composés non radiomarqués, des procédés de fabrication de ces composés et des procédés d'utilisation de ceux-ci afin de traiter divers troubles neurologiques et/ou psychiatriques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)