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1. (WO2011149102) HIGHLY IMMUNODEFICIENT MOUSE OPTIMIZED FOR BIOIMAGING
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/149102    International Application No.:    PCT/JP2011/062311
Publication Date: 01.12.2011 International Filing Date: 24.05.2011
Chapter 2 Demand Filed:    23.03.2012    
IPC:
A01K 67/027 (2006.01), C12Q 1/02 (2006.01), G01N 21/64 (2006.01), C12N 5/07 (2010.01), C12N 5/10 (2006.01), C12N 15/09 (2006.01)
Applicants: NATIONAL UNIVERSITY CORPORATION KUMAMOTO UNIVERSITY [JP/JP]; 2-39-1, Kurokami, Kumamoto-shi, Kumamoto 8608555 (JP) (For All Designated States Except US).
OKADA, Seiji [JP/JP]; (JP) (For US Only)
Inventors: OKADA, Seiji; (JP)
Agent: KOBAYASHI, Hiroshi; ABE, IKUBO & KATAYAMA, Fukuoka Bldg. 9th Fl., 8-7, Yaesu 2-chome, Chuo-ku, Tokyo 1040028 (JP)
Priority Data:
2010-118452 24.05.2010 JP
Title (EN) HIGHLY IMMUNODEFICIENT MOUSE OPTIMIZED FOR BIOIMAGING
(FR) SOURIS HAUTEMENT IMMUNODÉPRIMÉE OPTIMISÉE POUR L'IMAGERIE BIOLOGIQUE
(JA) 生体イメージングに最適化された高度免疫不全マウス
Abstract: front page image
(EN)Disclosed are: a hairless highly immunodeficient mouse which is suitable for bioimaging; and a bioimaging method which uses the mouse. Specifically disclosed is an immunodeficient mouse which has the following properties (a)-(c). (a) The mouse lacks T cells and B cells. (b) The NK activity is lost in the mouse. (c) The mouse is hairless.
(FR)La présente invention a trait à une souris hautement immunodéprimée sans poils qui convient à l'imagerie biologique ; et à un procédé d'imagerie biologique qui utilise la souris. Plus particulièrement, la présente invention a trait à une souris immunodéprimée qui est dotée des propriétés (a) à (c) suivantes. (a) La souris ne dispose ni de cellules T ni de cellules B. (b) L'activité NK est perdue chez la souris. (c) La souris est sans poils.
(JA) 本発明は、生体イメージングに適した無毛の高度免疫不全マウス及び当該マウスを用いた生体イメー ジング方法の提供を目的とする。 本発明は、以下の(a)~(c)の性質を有する免疫不全マウスに関する。(a) T細胞及びB細胞が欠損している(b) NK活性が消失している(c) 無毛である。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)