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Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/147951    International Application No.:    PCT/EP2011/058703
Publication Date: 01.12.2011 International Filing Date: 27.05.2011
C07D 401/14 (2006.01), C07D 409/14 (2006.01), C07D 413/14 (2006.01), C07D 417/14 (2006.01), C07D 487/04 (2006.01), C07D 491/08 (2006.01), A61K 31/454 (2006.01), A61P 3/10 (2006.01)
Applicants: PROSIDION LIMITED [GB/GB]; Lovett House Lovett Road Staines Middlesex TW18 3AZ (GB) (For All Designated States Except US).
BARBA, Oscar [IT/GB]; (GB) (For US Only).
BELL, James, Charles [GB/GB]; (GB) (For US Only).
DUPREE, Tom, Banksia [AU/AU]; (GB) (For US Only).
FRY, Peter, Timothy [GB/GB]; (GB) (For US Only).
BERTRAM, Lisa, Sarah [GB/GB]; (GB) (For US Only).
FYFE, Matthew, Colin, Thor [GB/GB]; (GB) (For US Only).
GATTRELL, William [GB/GB]; (GB) (For US Only).
JEEVARATNAM, Revathy, Perpetua [LK/GB]; (GB) (For US Only).
KEILY, John [GB/GB]; (GB) (For US Only).
KRULLE, Thomas, Martin [DE/GB]; (GB) (For US Only).
MCDONALD, Russell, Walker [GB/GB]; (GB) (For US Only).
MORGAN, Trevor [GB/GB]; (GB) (For US Only).
RASAMISON, Chrystelle, Marie [FR/GB]; (GB) (For US Only).
SCHOFIELD, Karen, Lesley [GB/GB]; (GB) (For US Only).
STEWART, Alan, John, William [GB/GB]; (GB) (For US Only).
SWAIN, Simon, Andrew [GB/GB]; (GB) (For US Only).
WITHALL, David, Matthew [GB/GB]; (GB) (For US Only)
Inventors: BARBA, Oscar; (GB).
BELL, James, Charles; (GB).
DUPREE, Tom, Banksia; (GB).
FRY, Peter, Timothy; (GB).
BERTRAM, Lisa, Sarah; (GB).
FYFE, Matthew, Colin, Thor; (GB).
GATTRELL, William; (GB).
JEEVARATNAM, Revathy, Perpetua; (GB).
KEILY, John; (GB).
KRULLE, Thomas, Martin; (GB).
MCDONALD, Russell, Walker; (GB).
MORGAN, Trevor; (GB).
RASAMISON, Chrystelle, Marie; (GB).
SCHOFIELD, Karen, Lesley; (GB).
STEWART, Alan, John, William; (GB).
SWAIN, Simon, Andrew; (GB).
WITHALL, David, Matthew; (GB)
Agent: RANDS, Peter David; Mintz Levin Cohn Ferris Glovsky & Popeo Intellectual Property LLP Alder Castle 10 Noble Street London, EC2V 7JX (GB)
Priority Data:
1008985.2 28.05.2010 GB
1019547.7 19.11.2010 GB
1103283.6 25.02.2011 GB
Abstract: front page image
(EN)Therapeutic compounds are disclosed having the general formula (I) that are useful for the treatment of metabolic disorders, including type II diabetes. The compounds have activity as agonists of GPR119. Compounds having the stereochemistry of formula (la) may also demonstrate DPP-IV inhibitory activity.
(FR)L'invention concerne des composés thérapeutiques de formule générale (I) que l'on utilise pour le traitement de troubles métaboliques, y compris le diabète de type II. Ces composés ont une activité comme agonistes du GPR119. Les composés ayant la stéréochimie de formule (Ia) peuvent également faire preuve d'une activité d'inhibition de DPP-IV.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)