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1. (WO2011147320) B CELL ACTIVATING FACTOR ANTAGONIST AND PREPARATION METHOD AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/147320    International Application No.:    PCT/CN2011/074687
Publication Date: 01.12.2011 International Filing Date: 26.05.2011
Chapter 2 Demand Filed:    26.03.2012    
IPC:
C07K 19/00 (2006.01), C12N 15/11 (2006.01), C12N 15/63 (2006.01), A61K 38/16 (2006.01), A61K 48/00 (2006.01), A61K 31/7088 (2006.01), A61P 19/02 (2006.01), A61P 19/04 (2006.01), A61P 29/00 (2006.01), A61P 37/02 (2006.01)
Applicants: CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY(SHIJIAZHUANG) CO., LTD. [CN/CN]; No.226 Huanghe Street Shijiazhuang Hebei 050035 (CN) (For All Designated States Except US).
SICHUAN UNIVERSITY [CN/CN]; No.24,South Section 1, First Ring Road, Wuhou District Chengdu, Sichuan 610065 (CN) (For All Designated States Except US).
YANG, Li [CN/CN]; (CN) (For US Only).
WEI, Yuquan [CN/CN]; (CN) (For US Only)
Inventors: YANG, Li; (CN).
WEI, Yuquan; (CN)
Agent: CHENGDU HONGQIAO PATENT LAW OFFICE; Room 13、15、16, 3rd Floor KEN Commerce Office Building, NO.22 South Section One, First Ring Road, Wuhou District Chengdu, Sichuan 610041 (CN)
Priority Data:
201010183905.9 26.05.2010 CN
Title (EN) B CELL ACTIVATING FACTOR ANTAGONIST AND PREPARATION METHOD AND USE THEREOF
(FR) ANTAGONISTE DU FACTEUR D'ACTIVATION DES LYMPHOCYTES B ET SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) B细胞激活因子拮抗剂及其制备方法与用途
Abstract: front page image
(EN)The present invention provides a new B cell activating factor (BAFF) antagonist and the use thereof, and the B cell activating factor antagonist is a fusion protein which comprises TACI receptor domain 2 binding to BAFF and Br3 receptor domain binding to BAFF. The fusion protein can further comprise an Fc fragment of human immunoglobulin and a signal peptide. The present invention also provides the use of the antagonist in the manufacture of medicaments for treating autoimmune diseases.
(FR)La présente invention concerne un nouvel antagoniste du facteur d'activation des lymphocytes B (BAFF) et son utilisation et l'antagoniste du facteur d'activation des lymphocytes B est une protéine de fusion qui comprend le domaine 2 du récepteur TACI se liant à BAFF et le domaine du récepteur Br3 se liant à BAFF. La protéine de fusion peut comprendre en outre un fragment Fc d'immunoglobuline humaine et un peptide signal. La présente invention concerne également l'utilisation de l'antagoniste dans la fabrication de médicaments pour le traitement de maladies auto-immunes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)