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1. (WO2011147185) IMMUNOSUPPRESSANT J2 - SODIUM ALGINATE MICROSPHERE, PREPARATION METHOD AND USE THEREOF

Pub. No.:    WO/2011/147185    International Application No.:    PCT/CN2010/080617
Publication Date: Dec 1, 2011 International Filing Date: Dec 31, 2010
IPC: A61K 9/16
A61K 31/404
A61K 47/36
A61P 37/06
Applicants: BEIJING HONGYIYAO SCIENCE & TECHNOLOGY DEVELOPMENT CO., LTD.
北京宏医耀科技发展有限公司
LI, Xinjian
李新建
HONG, Hong
洪宏
Inventors: LI, Xinjian
李新建
HONG, Hong
洪宏
Title: IMMUNOSUPPRESSANT J2 - SODIUM ALGINATE MICROSPHERE, PREPARATION METHOD AND USE THEREOF
Abstract:
An immunosuppressant J2 sodium alginate microsphere, its preparation method, and use are disclosed. The microsphere comprises sodium alginate as carrier and immunosuppressant J2. The micosphere is formed by encapsulating or absorbing immunosuppressant J2 into micosphere in presence of calcium ion through a high-voltage electrostatic droplets device. Said microsphere formulation has tissue-targeting, higher bioavailability and lower whole body toxicity.