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1. (WO2011147066) ARYLAMINO PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/147066    International Application No.:    PCT/CN2010/002126
Publication Date: 01.12.2011 International Filing Date: 23.12.2010
Chapter 2 Demand Filed:    05.03.2012    
IPC:
C07D 473/32 (2006.01), A61K 31/52 (2006.01), A61K 31/5377 (2006.01), A61P 35/00 (2006.01)
Applicants: CSPC ZHONGQI PHARMACEUTICAL TECHNOLOGY (SHIJIAZHUANG) CO., LTD [CN/CN]; No. 226 Huanghe Street Shijiazhuang, Hebei 050035 (CN) (For All Designated States Except US).
SI CHUAN UNIVERSITY [CN/CN]; No.24, South Section 1 First Ring Road, Wuhou District Chengdu, Sichuan 610065 (CN) (For All Designated States Except US).
YANG, Shengyong [CN/CN]; (CN) (For US Only).
WEI, Yuquan [CN/CN]; (CN) (For US Only)
Inventors: YANG, Shengyong; (CN).
WEI, Yuquan; (CN)
Agent: CHENGDU HONGQIAO PATENT LAW OFFICE; Room 13, 15, 16, 3rd Floor KEN Commerce Office Building, NO.22 South Section One, First Ring Road, Wuhou District Chengdu, Sichuan 610041 (CN)
Priority Data:
201010184478.6 26.05.2010 CN
Title (EN) ARYLAMINO PURINE DERIVATIVES, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF
(FR) DÉRIVÉS ARYLAMINÉS DE PURINE, LEUR PROCÉDÉ DE PRÉPARATION ET LEUR UTILISATION PHARMACEUTIQUE
(ZH) 芳胺基嘌呤衍生物及其制备方法和在医药上的用途
Abstract: front page image
(EN)Arylamino purine derivatives represented by formula I and their preparation method are disclosed, wherein each substituent is defined as in the description. The derivatives have an inhibitory effect on non-small cell lung cancer with deletion mutation of exon 19 or L858R point mutation of exon 21 in epidermal growth factor receptor (EGFR).
(FR)L'invention concerne des dérivés arylaminés de purine représentés par la formule I et leur procédé de préparation, dans lesquels chaque substituant est défini tel que dans la description. Les dérivés ont un effet inhibiteur sur le cancer du poumon non à petites cellules par une mutation de délétion de l'exon 19 ou la mutation ponctuelle L858R de l'exon 21 dans le récepteur du facteur de croissance épidermique (EGFR).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)