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Pub. No.:    WO/2011/146618    International Application No.:    PCT/US2011/037000
Publication Date: 24.11.2011 International Filing Date: 18.05.2011
C07D 215/28 (2006.01), C07D 215/38 (2006.01), C07D 405/06 (2006.01), C07D 409/06 (2006.01), A61K 31/47 (2006.01), A61K 31/4709 (2006.01), A61K 31/496 (2006.01), A61P 3/10 (2006.01), A61P 9/00 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, as represented by the secretary, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; Office of Technology Transfer, NIH 6011 Executive Boulevard, Suite 325 MSC 7600 Bethesda, Maryland 20892-7660 (US) (For All Designated States Except US).
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street Oakland, California 94607-5200 (US) (For All Designated States Except US).
EASTERN VIRGINIA MEDICAL SCHOOL [US/US]; Evms Norfolk, Virginia 23507 (US) (For All Designated States Except US).
THOMAS JEFFERSON UNIVERSITY [US/US]; 1020 Walnut Street Philadelphia, Pennsylvania 19107 (US) (For All Designated States Except US).
MALONEY, David J. [US/US]; (US) (For US Only).
HOLMAN, Theodore [US/US]; (US) (For US Only).
JADHAV, Ajit [US/US]; (US) (For US Only).
SIMEONOV, Anton [US/US]; (US) (For US Only).
BANTUKALLU, Ganesha Rai [IN/US]; (US) (For US Only).
NADLER, Jerry L. [US/US]; (US) (For US Only).
HOLINSTAT, Michael [US/US]; (US) (For US Only)
Inventors: MALONEY, David J.; (US).
HOLMAN, Theodore; (US).
JADHAV, Ajit; (US).
SIMEONOV, Anton; (US).
BANTUKALLU, Ganesha Rai; (US).
NADLER, Jerry L.; (US).
HOLINSTAT, Michael; (US)
Agent: PILLAI, Xavier; Leydig, Voit & Mayer, Ltd. Two Prudential Plaza Suite 4900 180 N. Stetson Avenue Chicago, Illinois 60601 (US)
Priority Data:
61/345,708 18.05.2010 US
Abstract: front page image
(EN)Disclosed are inhibitors of human 12-lipoxygenase of Formula (I) or (II), wherein R1, R2, R3, and R4 are as defined herein, that are useful in treating or preventing a 12-lipoxygenase mediated disease or disorder, e.g., diabetes. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal.
(FR)L'invention porte sur des inhibiteurs de la 12-lipoxygénase humaine de formule (I) ou (II), dans lesquelles R1, R2, R3 et R4 sont tels que définis dans la description, qui sont utiles dans le traitement ou la prévention d'une maladie ou d'un trouble à médiation par la 12-lipoxygénase, par exemple le diabète. L'invention porte également sur une composition comprenant un vecteur pharmaceutiquement acceptable ou au moins un inhibiteur de l'invention et sur une méthode de traitement ou de prévention d'une telle maladie ou d'un tel trouble chez un mammifère.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)