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Machine translation
1. (WO2011146568) PREDICTING RESPONSE TO A HER INHIBITOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/146568    International Application No.:    PCT/US2011/036927
Publication Date: 24.11.2011 International Filing Date: 18.05.2011
IPC:
A61K 39/395 (2006.01), G01N 33/574 (2006.01), C07K 16/32 (2006.01)
Applicants: GENENTECH, INC. [US/US]; 1 DNA Way South San Francisco, California 94080 (US) (AE, AG, AM, AO, AU, AZ, BB, BF, BH, BJ, BR, BW, BY, BZ, CA, CF, CG, CI, CL, CM, CO, CR, CU, DM, DO, DZ, EC, EG, GA, GD, GE, GH, GM, GN, GQ, GT, GW, HN, ID, IL, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LY, MA, MD, ME, MG, ML, MN, MR, MW, MX, MY, MZ, NA, NE, NG, NI, NZ, OM, PE, PG, PH, RU, SC, SD, SG, SL, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (AL, AT, BA, BE, BG, CH, CN, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IN, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR only).
AMLER, Lukas [DE/US]; (US) (For US Only).
MOECKS, Joachim [DE/CH]; (CH) (For US Only).
PAUL, Hubert [DE/CH]; (CH) (For US Only).
RUGE, Elisabeth [DE/CH]; (CH) (For US Only).
STRAUSS, Andreas [DE/CH]; (CH) (For US Only).
VENTURI, Miro [DE/CH]; (CH) (For US Only)
Inventors: AMLER, Lukas; (US).
MOECKS, Joachim; (CH).
PAUL, Hubert; (CH).
RUGE, Elisabeth; (CH).
STRAUSS, Andreas; (CH).
VENTURI, Miro; (CH)
Agent: LEE, Wendy, M.; Genentech, Inc. 1 DNA Way MS 49 South San Francisco, California 94080 (US)
Priority Data:
61/395,899 19.05.2010 US
Title (EN) PREDICTING RESPONSE TO A HER INHIBITOR
(FR) PRÉDICTION DE RÉPONSES À UN INHIBITEUR DE HER
Abstract: front page image
(EN)The present invention concerns methods for predicting response of patients with HER2 expressing tumor to treatment with HER inhibitors. In particular, the present invention concerns the use of low HER2 mRNA levels as a selection criterion for treating HER2 postive cancer patients, such as breast cancer patients, with HER inhibitor, such as pertuzumab.
(FR)La présente invention concerne des procédés de prédiction d'une réponse de patients ayant une tumeur exprimant HER2 vis-à-vis d'un traitement par des inhibiteurs de HER. En particulier, la présente invention concerne l'utilisation de faibles niveaux d'ARNm de HER2 comme critère de sélection pour le traitement de patients cancéreux positifs à HER2, tels que des patients atteints d'un cancer du sein, par un inhibiteur de HER, tel que le pertuzumab.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)