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1. (WO2011144714) KISSORPHIN PEPTIDES FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE, CREUTZFELDT- JAKOB DISEASE OR DIABETES MELLITUS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2011/144714 International Application No.: PCT/EP2011/058213
Publication Date: 24.11.2011 International Filing Date: 19.05.2011
Chapter 2 Demand Filed: 19.03.2012
IPC:
A61K 38/04 (2006.01) ,A61K 38/07 (2006.01) ,A61K 38/08 (2006.01) ,A61K 38/17 (2006.01) ,C07K 2/00 (2006.01) ,C07K 5/10 (2006.01) ,C07K 7/06 (2006.01) ,A61P 3/10 (2006.01) ,A61P 25/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
07
Tetrapeptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
04
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08
Peptides having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
2
Peptides of undefined number of amino acids; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
5
Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04
containing only normal peptide links
10
Tetrapeptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04
Linear peptides containing only normal peptide links
06
having 5 to 11 amino acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
08
for glucose homeostasis
10
for hyperglycaemia, e.g. antidiabetics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
MILTON, Nathaniel [GB/GB]; GB (UsOnly)
ROEHAMPTON UNIVERSITY [GB/GB]; Froebel College Roehampton Lane London SW15 5PJ, GB (AllExceptUS)
Inventors:
MILTON, Nathaniel; GB
Agent:
JAPPY, John; Gill Jennings & Every LLP The Broadgate Tower 20 Primrose Street London Greater London EC2A 2ES, GB
Priority Data:
10163479.820.05.2010EP
Title (EN) KISSORPHIN PEPTIDES FOR USE IN THE TREATMENT OF ALZHEIMER'S DISEASE, CREUTZFELDT- JAKOB DISEASE OR DIABETES MELLITUS
(FR) PEPTIDES KISSORPHINE POUR L'UTILISATION DANS LE TRAITEMENT DE LA MALADIE D'ALZHEIMER, LA MALADIE DE CREUTZFELDT-JAKOB OU LE DIABÈTE SUCRÉ
Abstract:
(EN) The present invention is directed to Kissorphin peptides (Tyr-Asn-Trp-Asn-Ser-Phe) and derivatives or analogs thereof that target Amyloid fibril-forming peptides. The Kissorphin peptides are highly specific therapeutic reagents that are useful in detecting, preventing and treating diseases associated with Amyloid fibril-forming peptides, such as Alzheimer's disease, Creutzfeldt-Jakob disease or Diabetes mellitus. According to the invention, a peptide comprises the amino acid sequence defined herein as SEQ ID No. 2, for use in the treatment of a condition associated with Amyloid fibril-forming peptides, wherein the peptide does not directly activate or inhibit the GPR-54 G-protein coupled receptor. Antibodies against Kissorphin peptides and methods for determining whether a subject has, or is predisposed to having, a disorder associated with Amyloid fibril formation are also described.
(FR) La présente invention concerne des peptides Kissorphine (Tyr-Asn-Trp-Asn-Ser-Phe) et des dérivés ou des analogues de ceux-ci qui ciblent des peptides formant des fibrilles amyloïdes. Les peptides Kissorphine sont des réactifs thérapeutiques hautement spécifiques qui sont utiles dans la détection, la prévention et le traitement de maladies associées à des peptides formant des fibrilles amyloïdes, telles que la maladie d'Alzheimer, la maladie de Creutzfeldt-Jakob ou le diabète sucré. Selon l'invention, un peptide comprend la séquence d'acides aminés définie dans la présente invention comme SEQ ID No. 2, pour l'utilisation dans le traitement d'un état associé à des peptides formant des fibrilles amyloïdes, le peptide n'activant ou n'inhibant pas directement le récepteur GPR-54 couplé à une protéine G. L'invention porte également sur des anticorps contre des peptides Kissorphine et sur des procédés de détermination dans le cas où un sujet présente ou est prédisposé à présenter un trouble associé à la formation de fibrilles amyloïdes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)