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1. (WO2011144657) PURIFICATION OF POSACONAZOLE AND OF POSACONAZOLE INTERMEDIATES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/144657    International Application No.:    PCT/EP2011/058039
Publication Date: 24.11.2011 International Filing Date: 18.05.2011
IPC:
C07D 405/06 (2006.01)
Applicants: SANDOZ AG [CH/CH]; Lichtstr. 35 CH-4056 Basel (CH) (For All Designated States Except US).
LANGNER, Martin [DE/AT]; (AT) (For US Only).
DE SOUZA, Dominic [AT/AT]; (AT) (For US Only).
PISE, Abhinay C. [IN/IN]; (IN) (For US Only).
BHUTA, Sachin [IN/IN]; (IN) (For US Only)
Inventors: LANGNER, Martin; (AT).
DE SOUZA, Dominic; (AT).
PISE, Abhinay C.; (IN).
BHUTA, Sachin; (IN)
Agent: ALTMANN, Andreas; Herzog Fiesser & Partner, Patent Attorneys Isartorplatz 1 80331 Munich (DE)
Priority Data:
10163210.7 19.05.2010 EP
Title (EN) PURIFICATION OF POSACONAZOLE AND OF POSACONAZOLE INTERMEDIATES
(FR) PURIFICATION DE POSACONAZOLE ET INTERMÉDIAIRES POUR LA PRÉPARATION DE POSACONAZOLE
Abstract: front page image
(EN)The present invention relates to a process for the preparation of a hydrogen chloride (HC1) salt of a compound of formula (I) wherein Y1 and Y2 are independently F or C1, preferably F, said compound of formula (I) containing the cis-isomer and the trans-isomer, wherein the process comprises (1) providing the compound of formula (I) comprised in a first suitable solvent; and (2) treating the compound of formula (I) comprised in the first suitable solvent with HC1 comprised in a second suitable solvent to obtain the HC1 salt of the compound of formula (I)·
(FR)La présente invention porte sur un procédé pour la préparation d'un sel de chlorure d'hydrogène (HCl) d'un composé de formule (I) dans laquelle Y1 et Y2 représentent chacun indépendamment F ou Cl, de préférence F, ledit composé de formule (I) contenant l'isomère cis et l'isomère trans, le procédé consistant à (1) utiliser le composé de formule (I) présent dans un premier solvant approprié ; et (2) traiter le composé de formule (I) présent dans le premier solvant approprié avec de l'HCl présent dans un second solvant approprié pour obtenir le sel de HCl du composé de formule (I).
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)