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1. (WO2011144584) PYRROLOPYRAZINE DERIVATIVES AS SYK AND JAK INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/144584    International Application No.:    PCT/EP2011/057910
Publication Date: 24.11.2011 International Filing Date: 17.05.2011
IPC:
C07D 487/04 (2006.01), A61K 31/4965 (2006.01), A61K 31/497 (2006.01), A61P 29/00 (2006.01), A61P 37/00 (2006.01), A61P 35/00 (2006.01), A61P 25/00 (2006.01), A61P 9/00 (2006.01), A61P 3/00 (2006.01), A61P 11/00 (2006.01), A61P 19/00 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (For All Designated States Except US).
HENDRICKS, Robert Than [US/US]; (US) (For US Only).
HERMANN, Johannes Cornelius [DE/US]; (US) (For US Only).
KONDRU, Rama K. [US/US]; (US) (For US Only).
LOU, Yan [CN/US]; (US) (For US Only).
LYNCH, Stephen M. [US/US]; (US) (For US Only).
OWENS, Timothy D. [US/US]; (US) (For US Only).
SOTH, Michael [US/US]; (US) (For US Only).
YEE, Calvin Wesley [US/US]; (US) (For US Only)
Inventors: HENDRICKS, Robert Than; (US).
HERMANN, Johannes Cornelius; (US).
KONDRU, Rama K.; (US).
LOU, Yan; (US).
LYNCH, Stephen M.; (US).
OWENS, Timothy D.; (US).
SOTH, Michael; (US).
YEE, Calvin Wesley; (US)
Agent: SALUD, Carlos; Grenzacherstrasse 124 CH-4070 Basel (CH)
Priority Data:
61/346,502 20.05.2010 US
61/475,286 14.04.2011 US
Title (EN) PYRROLOPYRAZINE DERIVATIVES AS SYK AND JAK INHIBITORS
(FR) DÉRIVÉS DE PYRROLOPYRAZINE COMME INHIBITEURS DE SYK ET JAK
Abstract: front page image
(EN)The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula (I), wherein the variables Q and R1 and R2 are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.
(FR)La présente invention porte sur l'utilisation de nouveaux dérivés de pyrrolopyrazine de formule (I), dans laquelle les variables Q, R1 et R2 sont telles que définies dans la description, qui inhibent JAK et SYK et sont utiles pour le traitement de maladies auto-immunes et inflammatoires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)