WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2011144358) HISTIDINE-CONTAINING SOLUTION FOR TRANSFECTION AND/OR INJECTION OF NUCLEIC ACIDS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/144358    International Application No.:    PCT/EP2011/002538
Publication Date: 24.11.2011 International Filing Date: 20.05.2011
IPC:
A61K 31/4172 (2006.01), A61K 47/18 (2006.01), A61K 48/00 (2006.01)
Applicants: CUREVAC GMBH [DE/DE]; Paul-Ehrlich-Str. 15 72076 Tübingen (DE) (For All Designated States Except US).
GORLOVOY, Philipp [DE/DE]; (DE) (For US Only).
SCHLAKE, Thomas [DE/DE]; (DE) (For US Only).
BAUMHOF, Patrick [DE/DE]; (DE) (For US Only)
Inventors: GORLOVOY, Philipp; (DE).
SCHLAKE, Thomas; (DE).
BAUMHOF, Patrick; (DE)
Agent: GRAF VON STOSCH, Andreas; GRAF VON STOSCH Patentanwaltsgesellschaft mbH Prinzregentenstrasse 22 80538 München (DE)
Priority Data:
10005373.5 21.05.2010 EP
Title (EN) HISTIDINE-CONTAINING SOLUTION FOR TRANSFECTION AND/OR INJECTION OF NUCLEIC ACIDS AND USES THEREOF
(FR) SOLUTION CONTENANT DE L'HISTIDINE POUR LA TRANSFECTION ET/OU L'INJECTION D'ACIDES NUCLÉIQUES ET SES UTILISATIONS
Abstract: front page image
(EN)The present invention is directed to a solution for transfection and/or injection containing at least one nucleic acid (sequence) and (free) histidine in a concentration of about 1 to about 25 μΜ. The present invention is also directed to the use of such histidine-containing solutions for transfection and/or injection of nucleic acid(s) (sequences), in particular for improvement of the transfection efficiency and/or endosomal release of nucleic acids. It is also directed to pharmaceutical compositions comprising such an inventive solution and its use as a medicament and/or for the prophylaxis, the treatment and/or the amelioration of various diseases as mentioned herein, e.g. by vaccination. The present invention is also directed to a method for transfection of a cell or an organism utilizing these inventive solutions and pharmaceutical compositions and to kits, comprising the inventive solution or pharmaceutical compositions thereof.
(FR)La présente invention concerne une solution pour la transfection et/ou l'injection contenant au moins un(e) (séquence de) acide nucléique et de l'histidine (libre) en une concentration d'environ 1 à environ 25 μΜ. La présente invention concerne également l'utilisation de ces solutions contenant de l'histidine pour la transfection et/ou l'injection de (séquences de) acide(s) nucléique(s), en particulier pour l'amélioration de l'efficacité de la transfection et/ou de la libération endosomale d'acides nucléiques. Elle concerne également des compositions pharmaceutiques comprenant une solution selon l'invention et son utilisation comme médicament et/ou pour la prophylaxie, le traitement et/ou l'amélioration de différentes maladies telles que mentionnées dans le présent document, par exemple par vaccination. La présente invention concerne également un procédé de transfection d'une cellule ou d'un organisme utilisant ces solutions selon l'invention et des compositions pharmaceutiques et des kits, comprenant la solution selon l'invention ou des compositions pharmaceutiques de celle-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)