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1. (WO2011143762) METHOD FOR REDUCING EXPRESSION OF DOWNREGULATED IΝ RENAL CELL CARCINOMA IΝ MALIGNANT GLIOMAS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/143762    International Application No.:    PCT/CA2011/000591
Publication Date: 24.11.2011 International Filing Date: 18.05.2011
IPC:
C12N 15/113 (2010.01), A61K 31/7088 (2006.01), A61P 35/00 (2006.01), C12N 15/85 (2006.01)
Applicants: THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING / MCGILL UNIVERSITY [CA/CA]; 845 Sherbrooke Street West Montréal, Québec H3S 2T5 (CA) (For All Designated States Except US).
PETRECCA, Kevin [CA/CA]; (CA) (For US Only).
DAMHA, Masad [CA/CA]; (CA) (For US Only).
DELEAVEY, Glen [CA/CA]; (CA) (For US Only)
Inventors: PETRECCA, Kevin; (CA).
DAMHA, Masad; (CA).
DELEAVEY, Glen; (CA)
Agent: NORTON ROSE CANADA LLP/S.E.N.C.R.L., S.R.L.; Suite 2500 1 place Ville-Marie Montreal, Québec H3B 1R1 (CA)
Priority Data:
61/345,751 18.05.2010 US
Title (EN) METHOD FOR REDUCING EXPRESSION OF DOWNREGULATED IΝ RENAL CELL CARCINOMA IΝ MALIGNANT GLIOMAS
(FR) PROCÉDÉ DE RÉDUCTION DE L'EXPRESSION DE GÈNES RÉGULÉS À LA BAISSE DANS DES HYPERNÉPHROMES DANS DES GLIOMES MALINS
Abstract: front page image
(EN)The present invention relates to novel compositions and therapeutic methods for the treatment of cancer, in particular malignant glioma. The compositions include antisense oligonucleotides or RNAs or vectors encoding them which reduce expression of downregulated in renal cell carcinoma (DRR) in tumor cells, and inhibit malignant glioma cell invasion.
(FR)La présente invention concerne des compositions et méthodes thérapeutiques nouvelles pour le traitement de cancers, en particulier des gliomes malins. Les compositions comprennent des oligonucléotides ou des ARN antisens ou des vecteurs codant pour ceux-ci qui réduisent l'expression de gènes régulés à la baisse dans des hypernéphromes (DRR) dans des cellules tumorales et inhibent l'invasion par des cellules de gliomes malins.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)