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1. (WO2011143593) CONJUGATES OF A LIPOIC ACID DERIVATIVE AND ANTI-PROLIFERATION AGENT AND MEDICAL USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/143593    International Application No.:    PCT/US2011/036491
Publication Date: 17.11.2011 International Filing Date: 13.05.2011
IPC:
C07H 19/02 (2006.01), A61K 31/513 (2006.01), A61P 35/00 (2006.01)
Applicants: CORNERSTONE PHARMACEUTICALS, INC. [US/US]; 1 Duncan Drive Cranbury, NJ 08512-3629 (US) (For All Designated States Except US).
SHORR, Robert, G.l. [US/US]; (US) (For US Only).
RODRIGUEZ, Robert, J. [US/US]; (US) (For US Only).
BOTEJU, Lakmal [US/US]; (US) (For US Only)
Inventors: SHORR, Robert, G.l.; (US).
RODRIGUEZ, Robert, J.; (US).
BOTEJU, Lakmal; (US)
Agent: DAVIS, Chad, E.; Goodwin Procter LLP Exchange Place Boston, MA 02109 (US)
Priority Data:
61/344,053 14.05.2010 US
Title (EN) CONJUGATES OF A LIPOIC ACID DERIVATIVE AND ANTI-PROLIFERATION AGENT AND MEDICAL USES THEREOF
(FR) CONJUGUÉS DE DÉRIVÉ D'ACIDE LIPOÏQUE ET D'AGENT ANTIPROLIFÉRATIF ET LEURS UTILISATIONS MÉDICALES
Abstract: front page image
(EN)The invention provides conjugate compounds, pharmaceutical compositions, therapeutic methods, and kits for use in treating cell proliferation disorders, such as cancer. The conjugates comprise a redox-modulating compound, such as a lipoic acid derivative, chemically bonded to an anti-proliferation agent, such as gemcitabine.
(FR)L'invention concerne des composés conjugués, des compositions pharmaceutiques, des méthodes thérapeutiques et des nécessaires devant être utilisés dans le traitement de troubles de prolifération cellulaire, tels que le cancer. Les conjugués comportent un composé modulateur d'oxydoréduction, tel qu'un dérivé d'acide lipoïque, lié chimiquement à un agent antiprolifératif, tel que la gemcitabine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)