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1. (WO2011143422) 2 -AMINOPYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF ATR KINASE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/143422    International Application No.:    PCT/US2011/036242
Publication Date: 17.11.2011 International Filing Date: 12.05.2011
IPC:
C07D 213/82 (2006.01), C07D 413/04 (2006.01), C07D 413/14 (2006.01), A61K 31/4439 (2006.01), A61P 35/00 (2006.01)
Applicants: VERTEX PHARMACEUTICALS INCORPORATED [US/US]; 130 Waverly Street Cambridge, MA 02139 (US) (For All Designated States Except US).
CHARRIER, Jean-Damien [FR/GB]; (GB) (For US Only).
DURRANT, Steven, John [GB/GB]; (GB) (For US Only).
KNEGTEL, Ronald, Marcellus Alphonsus [NL/GB]; (GB) (For US Only).
REAPER, Philip, Michael [GB/GB]; (GB) (For US Only)
Inventors: CHARRIER, Jean-Damien; (GB).
DURRANT, Steven, John; (GB).
KNEGTEL, Ronald, Marcellus Alphonsus; (GB).
REAPER, Philip, Michael; (GB)
Agent: CHE, Jennifer, G.; Vertex Pharmaceuticals Incorporated 130 Waverly Street Cambridge, MA 02139 (US)
Priority Data:
61/333,854 12.05.2010 US
Title (EN) 2 -AMINOPYRIDINE DERIVATIVES USEFUL AS INHIBITORS OF ATR KINASE
(FR) DÉRIVÉS DE 2-AMINOPYRIDINE UTILES EN TANT QU'INHIBITEURS DE LA KINASE ATR
Abstract: front page image
(EN)The present invention relates to pyridine compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors. The compounds of this invention have formula (III): (Formula (III) wherein the variables are as defined herein.
(FR)La présente invention concerne des composés de pyridine utiles en tant qu'inhibiteurs de la protéine kinase ATR. L'invention concerne également des compositions pharmaceutiquement acceptables contenant les composés de cette invention ; des méthodes de traitement de diverses maladies, divers troubles et diverses affections à l'aide des composés de cette invention ; des procédés de préparation des composés de cette invention ; des intermédiaires pour la préparation des composés de cette invention ; et des méthodes d'utilisation des composés dans des applications in vitro, telles que l'étude de kinases dans des phénomènes biologiques et pathologiques ; l'étude des voies de transduction des signaux intracellulaires médiées par de telles kinases ; et l'évaluation comparative de nouveaux inhibiteurs de kinases. Les composés de cette invention sont de formule (III): (Formule (III) dans laquelle les variables sont telles que définies dans ce document.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)