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1. (WO2011143230) METHODS AND COMPOSITIONS FOR DELIVERY OF ACTIVE AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2011/143230    International Application No.:    PCT/US2011/035939
Publication Date: 17.11.2011 International Filing Date: 10.05.2011
IPC:
A61K 9/127 (2006.01), A61K 48/00 (2006.01)
Applicants: ALNYLAM PHARMACEUTICALS [US/US]; 300 Third Street Cambridge, MA 02142 (US) (For All Designated States Except US).
MANOHARAN, Muthiah [US/US]; (US) (For US Only).
RAJEEV, Kallanthottathil G. [IN/US]; (US) (For US Only)
Inventors: MANOHARAN, Muthiah; (US).
RAJEEV, Kallanthottathil G.; (US)
Agent: LESSLER, Jay, P.; Blank Rome LLP The Chrysler Building 405 Lexington Avenue New York, New York 10174 (US)
Priority Data:
61/333,122 10.05.2010 US
Title (EN) METHODS AND COMPOSITIONS FOR DELIVERY OF ACTIVE AGENTS
(FR) PROCÉDÉS ET COMPOSITIONS POUR LA DISTRIBUTION D'AGENTS ACTIFS
Abstract: front page image
(EN)A lipid particle can include a cationic lipid. Synthesis of the cationic lipid can include a ylide-based reaction, such as a Wittig reaction or sulfur ylide reaction. In some cases, the synthesis can also include a Michael addition or a related addition reaction.
(FR)Selon la présente invention, une particule lipidique peut comprendre un lipide cationique. La synthèse du lipide cationique peut comprendre une réaction à base d'ylure, telle qu'une réaction de Wittig ou une réaction avec un ylure de soufre. Dans certains cas, la synthèse peut aussi comprendre une addition de Michael ou une réaction d'addition associée.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)